临床与病理杂志2026，Vol.46Issue(1)：89-98,10.DOI:10.11817/j.issn.2095-6959.2026.250880
DNA甲基化与口腔扁平苔藓的发病机制
DNA methylation and the pathogenesis of oral lichen planus
摘要
Abstract
Oral lichen planus(OLP)is a chronic inflammatory disease of the oral mucosa with a high incidence,characterized primarily by T-cell-mediated immune dysregulation and carrying a potential risk of malignant transformation.DNA methylation,as an important epigenetic regulatory mechanism,participates in the pathogenesis of OLP by influencing the expression of immune-related genes.Environmental factors and genetic polymorphisms can lead to abnormal DNA methylation patterns,thereby affecting T cell function,cytokine secretion,and the regulation of inflammatory responses.In patients with OLP,characteristic methylation alterations have been identified in various immune-related genes,microRNAs,and transcription factors.These changes not only participate in the occurrence and development of the disease but are also closely associated with disease activity and malignant transformation.DNA methylation,through the regulation of gene expression,has been increasingly studied in relation to pathogenesis,disease assessment,and prediction of malignant transformation in OLP,providing important theoretical support for the development of novel diagnostic biomarkers and targeted therapeutic strategies.关键词
口腔扁平苔藓/DNA甲基化/发病机制/甲基化标志物/微RNAKey words
oral lichen planus/DNA methylation/pathogenesis/methylation markers/microRNA分类
医药卫生引用本文复制引用
李凯,邓睿恒,朱慧敏,常瑜,成志勇..DNA甲基化与口腔扁平苔藓的发病机制[J].临床与病理杂志,2026,46(1):89-98,10.基金项目
河北省重点研发计划(223777105D).This work was supported by the Key Research and Development Project of Hebei Province,China(223777105D). （223777105D）
