临床与病理杂志2026，Vol.46Issue(1)：112-120,9.DOI:10.11817/j.issn.2095-6959.2026.250982
线粒体自噬在糖尿病周围神经病变中的作用
Role of mitophagy in diabetic peripheral neuropathy
摘要
Abstract
Diabetic peripheral neuropathy(DPN)is one of the most common chronic complications of diabetes and seriously affects patients'quality of life.Its pathogenesis is complex and involves multiple pathological processes,including metabolic disorders,oxidative stress,and mitochondrial dysfunction.In recent years,mitophagy,as a key cellular quality-control mechanism for the selective removal of damaged mitochondria,has received increasing attention in DPN.Studies have shown that mitophagy can regulate the progression of DPN by maintaining mitochondrial homeostasis and alleviating oxidative stress and inflammatory responses.At present,the specific molecular mechanisms and potential therapeutic value of mitophagy in DPN remain unclear and require further in-depth investigation.A systematic summary of the molecular regulatory network of mitophagy,an in-depth discussion of its role in the occurrence and development of DPN,and an analysis of therapeutic strategies targeting mitophagy and their clinical application prospects are expected to provide a theoretical basis and research ideas for understanding the pathogenesis of DPN and developing innovative treatment strategies.关键词
糖尿病周围神经病变/线粒体自噬/氧化应激/分子机制/治疗靶点Key words
diabetic peripheral neuropathy/mitophagy/oxidative stress/molecular mechanisms/therapeutic targets分类
医药卫生引用本文复制引用
田刚,吕海宏..线粒体自噬在糖尿病周围神经病变中的作用[J].临床与病理杂志,2026,46(1):112-120,9.基金项目
甘肃省科技计划(24JRRA1087) （24JRRA1087）
甘肃省高校教师创新基金项目(2025B-007) （2025B-007）
兰州大学第一医院院内项目(ldyyyn2023-85).This work was supported by the Science and Technology Program of Gansu Province(24JRRA1087),the University Teacher Innovation Fund of Gansu Province(2025B-007),and the Fund of First Hospital of Lanzhou University(ldyyyn2023-85),China. （ldyyyn2023-85）
