神经损伤与功能重建2026，Vol.21Issue(3)：156-161,6.DOI:10.16780/j.cnki.sjssgncj.20251375
胶质-血管单元参与皮层扩散性抑制进程的研究进展
Research Progress on the Involvement of the Glial-Vascular Unit in Cortical Spreading Depression
摘要
Abstract
Cortical spreading depression(CSD)is a key pathological event in various neurological disorders such as migraine and cerebral ischemia.Recent research reveals that the glial-vascular unit(GVU)serves as a central platform regulating the CSD process.This review systematically elucidates the dynamic roles and mechanisms of GVU components in CSD:the dual functions of astrocytes as central hubs;microglia acting as one of initiating cells potentially involved in both damaging and reparative effects;abnormal post-CSD contraction of pericytes mediating sustained capillary hypoperfusion;while functional alterations in the perivascular space and glymphatic system may represent potential factors influencing CSD initiation and recovery.These findings establish the GVU as the core regulatory platform for CSD,whose internal synergy and conflicts determine disease progression.This shifts the research focus from individual components to the entire GVU,providing novel perspectives for comprehensively understanding CSD pathophysiology and developing multi-target synergistic therapeutic strategies.关键词
胶质细胞/皮层扩散性抑制/胶质-血管单元Key words
glial cells/cortical spreading depression/glial-vascular unit分类
医药卫生引用本文复制引用
杨霄,姚笛,汪明欢..胶质-血管单元参与皮层扩散性抑制进程的研究进展[J].神经损伤与功能重建,2026,21(3):156-161,6.基金项目
湖北省自然科学基金(脑小血管病介导认知功能损害的机制及干预靶点,No.2022CFA097) （脑小血管病介导认知功能损害的机制及干预靶点,No.2022CFA097）
国家自然科学基金(mLVs-Glymphatic系统在急性脑梗塞后神经血管单元损伤与功能重塑中的作用及机制研究,No.822713559) （mLVs-Glymphatic系统在急性脑梗塞后神经血管单元损伤与功能重塑中的作用及机制研究,No.822713559）
国家自然青年科学基金项目(Col3a1+周细胞介导AQP4极化调控Glymphatic系统功能——血管性认知障碍的干预新靶点?,No.82401566) （Col3a1+周细胞介导AQP4极化调控Glymphatic系统功能——血管性认知障碍的干预新靶点?,No.82401566）
