神经损伤与功能重建2026，Vol.21Issue(3)：162-167,6.DOI:10.16780/j.cnki.sjssgncj.20251485
经鼻脑给药途径治疗在中枢神经系统脱髓鞘疾病中的研究进展
Research Progress on Nose-to-Brain Delivery for Treating Central Nervous System Demyelinating Diseases
摘要
Abstract
Central nervous system demyelinating diseases,represent a group of chronic autoimmune conditions requiring long-term intervention.Traditional systemic administration methods face limitations due to the blood-brain barrier,resulting in issues such as low central nervous system delivery efficiency,high systemic exposure,and significant interindividual pharmacokinetic variability.These factors compromise treatment precision and patient compliance.The Nose-to-Brain(N2B)route bypasses the blood-brain barrier via the olfactory and trigeminal pathways,enabling direct central drug delivery with advantages including non-mvasiveness,high targeting specificity,and minimal systemic side effects.This study systematically reviews the dual-pathway delivery mechanism of this route,along with recent advances in reducing neuroinflammation,promoting myelin regeneration,and neuroprotective delivery strategies.It also analyzes current challenges in clinical translation.关键词
鼻脑给药/中枢神经系统脱髓鞘疾病/血脑屏障/治疗Key words
Nose-to-Brain delivery/central nervous system demyelinating diseases/blood-brain barrier/treatment分类
医药卫生引用本文复制引用
毛嘉玲,王满侠..经鼻脑给药途径治疗在中枢神经系统脱髓鞘疾病中的研究进展[J].神经损伤与功能重建,2026,21(3):162-167,6.基金项目
甘肃省神经病学疾病精准诊疗国际合作基地(甘科外[2017]2-33号) （甘科外[2017]2-33号）
甘肃省级重点人才项目甘组通字[2022]77号-6 （）
甘肃省自然科学基金(基于多组学联合探讨肠道菌群介导NMOSD发病机制研究,No.24JRRA352) （基于多组学联合探讨肠道菌群介导NMOSD发病机制研究,No.24JRRA352）
甘肃省自然科学基金(莫诺苷调控小胶质细胞内质网应激保护实验性自身免疫性脑脊髓炎的作用机制研究,No.25JRRA615) （莫诺苷调控小胶质细胞内质网应激保护实验性自身免疫性脑脊髓炎的作用机制研究,No.25JRRA615）
