保健医学研究与实践2026，Vol.23Issue(1)：52-57,65,7.DOI:10.11986/j.issn.1673-873X.2026.01.09
D-D/FDP比值与消化性溃疡并发上消化道出血的关系
Relationship between D-D/FDP ratio and concurrent upper gastrointestinal bleeding in patients with peptic ulcer
摘要
Abstract
Objective To investigate the relationship between the D-dimer/fibrinogen degradation product(D-D/FDP)ratio and concurrent upper gastrointestinal bleeding(UGIB)in patients with peptic ulcer(PU),providing a basis for risk predic-tion and targeted intervention among this population.Methods A total of 160 patients with PU admitted to the No.2 Hos-pital of Baoding from June 2022 to April 2024 were enrolled and assigned to concurrent UGIB(n=34)and non-concurrent UGIB groups(n=126)based on whether UGIB occurred.General data were compared between the two groups,and logistic regression analysis was used to explore factors influencing concurrent UGIB in PU patients.The D-D/FDP ratio was com-pared between the two groups,and receiver operating characteristic(ROC)curve analysis with area under the curve(AUC)was employed to evaluate the predictive value of the D-D/FDP ratio for concurrent UGIB.Results Serum D-D and FDP lev-els and the D-D/FDP ratio were significantly higher in the concurrent UGIB group than in the non-concurrent UGIB group(P<0.05).The AUCs of D-D,FDP,and the D-D/FDP ratio for predicting concurrent UGIB in patients with PU were 0.820(95%CI:0.775-0.865),0.764(95%CI:0.719-0.814),and 0.913(95%CI:0.863-0.963),respectively.The AUC of the D-D/FDP ratio was significantly greater than that of D-D or FDP alone(Z=9.327,11.043;both P<0.05).No statistically significant differences were found between the two groups in gender composition,duration of dis-ease,ulcer location,or place of residence(P>0.05).The concurrent UGIB group had significantly higher proportions of patients aged≥60 years,with ulcer diameter≥20 mm,active stage ulcers,manual occupation,and Helicobacter pylori(Hp)infection than the non-concurrent UGIB group(P<0.05).Multivariate logistic regression analysis identified ulcer di-ameter≥20 mm(OR=2.795,95%CI:1.689-4.626),active stage ulcers(OR=3.575,95%CI:1.876-6.813),Hp infection(OR=4.707,95%CI:2.270-9.758),and D-D/FDP ratio≥61.08(OR=4.865,95%CI:2.563-9.234)as risk factors for concurrent UGIB in PU patients(P<0.05).Conclusion The D-D/FDP ratio is closely associated with con-current UGIB in patients with PU and may serve as a potential indicator for predicting bleeding risk.In clinical practice,ear-ly identification of high-risk patients should be based on the D-D/FDP ratio combined with ulcer diameter,stage,and Hp in-fection status,enabling risk-stratified management and optimized preventive strategies to reduce UGIB incidence and im-prove patient prognosis.关键词
消化性溃疡/上消化道出血/D-二聚体/纤维蛋白原降解产物比值/预测价值Key words
Peptic ulcer/Upper gastrointestinal bleeding/D-dimer/fibrinogen degradation product ratio/Predictive value分类
医药卫生引用本文复制引用
董巍巍,周杨,贾丹,孙艳华,张惠萍,周辰光,聂李安娜,李书英,宋立明..D-D/FDP比值与消化性溃疡并发上消化道出血的关系[J].保健医学研究与实践,2026,23(1):52-57,65,7.基金项目
河北省中医药管理局科研计划项目(2023466). （2023466）
