工业微生物2026，Vol.56Issue(1)：13-16,4.DOI:10.3969/j.issn.1001-6678.2026.01.005
和厚朴酚对痤疮丙酸杆菌体外抑制作用的研究
Study on the in Vitro Inhibitory Effect of Honokiol against Cutibacterium acnes
郭惠珊 1李佳明 1甘礼社 2徐学涛 3邱晓锋4
作者信息
- 1. 五邑大学药学与食品工程学院,江门 529020||诺斯贝尔化妆品股份有限公司,中山 528427
- 2. 浙江中医药大学药学院,杭州 310053
- 3. 五邑大学药学与食品工程学院,江门 529020
- 4. 诺斯贝尔化妆品股份有限公司,中山 528427
- 折叠
摘要
Abstract
This article focused on investigating the in vitro inhibitory effects of honokiol on Cutibacterium acnes(C.acnes)and its mechanism of action.The antibacterial activity was assessed using the agar diffusion method,broth microdilution method,and time-kill curve.The effects of honokiol on C.acnes surface hydrophobicity,biofilm formation,and metabolic activity were analyzed through the microbial adhesion to hydrocarbons(MATH)test,crystal violet staining method,and MTT assay.Additionally,morphological changes in bacterial cells were observed using scanning electron microscopy(SEM).Results demonstrated that honokiol exhibited significant concentration-dependent antibacterial effects against C.acnes,with a minimum inhibitory concentration(MIC)of 15.63 μg/mL and a minimum bactericidal concentration(MBC)of 31.25 μg/mL.At MIC or higher concentrations,complete bacterial growth inhibition was achieved within 56 hours.Multidimensional experiments revealed that honokiol likely exerts its antibacterial effects by altering bacterial surface hydrophobicity,inhibiting biofilm formation,and disrupting cell integrity.The study indicated that honokiol displays multi-target antibacterial effects against C.acnes,providing reference for the development of natural antibacterial agents in acne treatment.关键词
和厚朴酚/痤疮丙酸杆菌/体外抑制作用/抑菌机理Key words
honokiol/Cutibacterium acnes/in vitro inhibitory effect/antibacterial mechanism引用本文复制引用
郭惠珊,李佳明,甘礼社,徐学涛,邱晓锋..和厚朴酚对痤疮丙酸杆菌体外抑制作用的研究[J].工业微生物,2026,56(1):13-16,4.
