工业微生物2026，Vol.56Issue(1)：59-61,3.DOI:10.3969/j.issn.1001-6678.2026.01.019
血清KRT18水平对肺腺癌TNM分期的影响及其诊断价值研究
Serum KRT18 Levels in Lung Adenocarcinoma:Impact on TNM Staging and Diagnostic Value
摘要
Abstract
This study investigated the expression levels of serum cytokeratin 18(KRT18)in patients with lung adenocarcinoma and its diagnostic value for lung adenocarcinoma.Serum KRT18 levels were measured using enzyme-linked immunosorbent assay(ELISA)in 30 patients and 30 healthy controls,supplemented by bioinformatics validation.Serum KRT18 levels were significantly elevated in patients(150.25±21.32 ng/mL)versus controls(51.56±10.04 ng/mL,P<0.001).Its expression level was closely correlated with TNM staging,showing marked increases in advanced-stage subgroups(T3&T4,N1&N3,M1;P<0.01-0.001).Receiver operating characteristic(ROC)curve analysis demonstrated diagnostic utility with an area under the curve(AUC)of 0.783(95%CI:0.545-0.930).The results indicated that the significant elevation of serum KRT18 levels in patients with lung adenocarcinoma was correlated with aggressive clinicopathological features of lung adenocarcinoma,indicating that serum KRT18 levels have the potential to serve as diagnostic and prognostic biomarkers for lung adenocarcinoma.关键词
血清/肺腺癌/KRT18/TNM分期Key words
serum/lung adenocarcinoma/KRT18/TNM stage引用本文复制引用
李勇杰,曾敏,封芬,魏海谅,马红玉..血清KRT18水平对肺腺癌TNM分期的影响及其诊断价值研究[J].工业微生物,2026,56(1):59-61,3.基金项目
湖南省教育厅科研项目(编号:24C0391) （编号:24C0391）
湖南省自然科学基金(编号:2024JJ7488). （编号:2024JJ7488）
