工业微生物2026，Vol.56Issue(1)：89-92,4.DOI:10.3969/j.issn.1001-6678.2026.01.028
发酵源N-乙酰氨基葡萄糖和氨基葡萄糖盐酸盐药代动力学研究
Pharmacokinetic Study of N-acetylglucosamine and Glucosamine Hydrochloride from Biofermentation Sources
卢健行 1刘晶晶 2纪香平 2张倩 3袁涛 1张化朋1
作者信息
- 1. 山东润德生物科技有限公司,新泰 271200
- 2. 山东润德生物科技有限公司,新泰 271200||山东省氨基葡萄糖及其衍生物技术创新中心,新泰 271200
- 3. 山东省氨基葡萄糖及其衍生物技术创新中心,新泰 271200
- 折叠
摘要
Abstract
The paper focused on comparing the pharmacokinetic characteristics of N-acetylglucosamine(NAG)and glucosamine hydrochloride(GH)from biofermentation sources.After intravenous and oral administration,the drug concentration in the plasma of SD rats was measured by using liquid chromatography-tandem mass spectrometry(LC-MS/MS)..After intravenous injection,Cmax,MRT0→t,and AUC0→t of NAG were significantly higher than those of GH(P<0.05);after oral administration,Cmax,and AUC0→t of NAG were also significantly higher than those of GH(P<0.05).The result indicated that NAG had better systemic exposure and absorption rate under both administration routes compared with GH.关键词
生物发酵/N-乙酰氨基葡萄糖/氨基葡萄糖盐酸盐/LC-MS/MS/药代动力学Key words
biological fermentation/N-acetylglucosamine/glucosamine hydrochloride/LC-MS/MS/pharmacokinetics引用本文复制引用
卢健行,刘晶晶,纪香平,张倩,袁涛,张化朋..发酵源N-乙酰氨基葡萄糖和氨基葡萄糖盐酸盐药代动力学研究[J].工业微生物,2026,56(1):89-92,4.
