四川大学学报（医学版）2026，Vol.57Issue(2)：473-481,9.DOI:10.12182/20260360109
抗核抗体阳性大样本人群中着丝点F样型免疫荧光模型的检出率及临床意义
The Prevalence and Clinical Significance of the Centromere Protein-F-Like Immunofluorescence Staining Pattern in a Large ANA-positive Cohort
摘要
Abstract
Objective To investigate the prevalence and clinical significance of the centromere protein-F-like(CENP-F-like)immunofluorescence staining pattern in a large patient cohort and through literature review.Methods We retrospectively analyzed antinuclear antibody(ANA)immunofluorescence assay results from 191 274 patients at West China Hospital of Sichuan University between March 2018 and November 2020.Specific immunological markers were tested in sera with CENP-F-like patterns.Additionally,a narrative review of seven relevant studies was performed for comparison.Results In Southwest China,ANA positivity was found in 32.09%of patients,with the CENP-F-like pattern detected in 0.015%of all cases and 0.05%of ANA-positive individuals.The CENP-F-like pattern appeared predominantly at titers≥1∶320,most often in isolation(68.97%),but also mixed with cytoplasmic speckled patterns.Patients with cancers accounted for the highest proportion(31.03%),including solid tumors and hematologic malignancies.Metastasis was observed in patients with solid tumors,while graft-versus-host disease(GVHD)occurred in those with hematologic malignancies post-transplantation.Autoimmune diseases(AIDs)were diagnosed in 20.69%of cases,all showing disease-specific autoantibodies.These findings were broadly consistent with previous reports and suggest a possible association between the CENP-F-like pattern and malignancies.Conclusion The CENP-F-like pattern is rare in ANA tests but may be associated with clinically important conditions,particularly cancers and AIDs.The occurrence of metastasis and GVHD in patients with this pattern highlights its potential clinical relevance,and concurrent autoantibodies may assist in diagnosing AIDs.关键词
抗体,抗核/荧光抗体技术,间接/临床相关性/肿瘤/自身免疫病Key words
Antibodies,antinuclear/Fluorescent antibody technique,indirect/Clinical relevance/Neoplasms/Autoimmune diseases引用本文复制引用
苏真珍,黄卓春,张凤,张丽静,哈依萨尔·叶尔肯,杨滨,胡静,王丽,高雪丹,张君龙..抗核抗体阳性大样本人群中着丝点F样型免疫荧光模型的检出率及临床意义[J].四川大学学报（医学版）,2026,57(2):473-481,9.基金项目
This study was supported by the National Key R&D Program of China(No.2022YFC2406600/No.2022YFC2406604). 国家重点研发计划项目(No.2022YFC2406600、No.2022YFC2406604)资助 （No.2022YFC2406600/No.2022YFC2406604）
