四川大学学报（医学版）2026，Vol.57Issue(2)：491-498,8.DOI:10.12182/20260360105
针刺蝶腭神经节治疗变应性鼻炎的临床随机对照试验
A Randomized Controlled Clinical Trial of Acupuncture at the Sphenopalatine Ganglion for the Treatment of Allergic Rhinitis
摘要
Abstract
Objective To evaluate the clinical efficacy and safety of acupuncture at the sphenopalatine ganglion(SPG)for the treatment of allergic rhinitis(AR).Methods A randomized controlled trial design was used.A total of 120 patients with AR were randomly assigned in a 1∶1 ratio to either the experimental group(acupuncture on the SPG,twice a week for 2 weeks)or the control group(oral lupatadine fumarate tablets,10 mg daily for 2 weeks).The primary outcome measures were nasal symptom and sign scores at 1 and 2 weeks after treatment.Secondary outcome measures included the total non-nasal symptom score(TNNSS)and the rhinoconjunctivitis quality of life questionnaire(RQLQ)score.Results Four cases were excluded from both the experimental group and the control group.Ultimately,56 cases in each group completed the study.After two weeks of treatment,the total effective rates were 82.1%for the experimental group and 87.5%for the control group,with no statistically significant difference.At each time point after treatment,the symptom scores,sign scores,TNNSS,and RQLQ scores in both groups decreased compared to baseline,and these differences were statistically significant(P<0.001).Generalized estimating equation(GEE)analysis showed that the improvement trends for most indicators were consistent between the two groups,but there was a"group×time"interaction,indicating that improvement in nasal congestion symptoms in the experimental group was greater than in the control group during the first week of treatment(experimental group:2.0[1.0,2.0]vs.control group:2.0[1.0,2.0],interaction P=0.023).Forest plot analysis further showed that the standardized mean difference(SMD)for nasal congestion symptoms at one week of treatment was －0.420(95%confidence interval:－0.795,－0.046),and the 95%confidence intervals for all indicators'SMD at two weeks crossed zero.Regarding safety,there was no statistically significant difference in the incidence of adverse events between the experimental and control groups.Conclusion Acupuncture on the SPG and oral administration of lupatadine fumarate can both effectively alleviate symptoms and improve the quality of life for patients with AR.The overall short-term efficacy is comparable.However,acupuncture on the SPG is more effective in relieving nasal congestion and has a good safety profile.关键词
针刺/蝶腭神经节/变应性鼻炎/随机对照试验Key words
Acupuncture/Sphenopalatine ganglion/Allergic rhinitis/Randomized controlled trial引用本文复制引用
黄觉之,钟彬毓,王凤瑶,张迎霞,邱燕,魏鱈钰,邓婧,宋红梅..针刺蝶腭神经节治疗变应性鼻炎的临床随机对照试验[J].四川大学学报（医学版）,2026,57(2):491-498,8.基金项目
This study was supported by Science and Technology Special Project of the Sichuan Administration of Traditional Chinese Medicine(No.2023MS325)and Key Research and Development Project of the Science and Technology Department of Sichuan Province(No.2023YFS0324). 四川省中医药管理局科学技术专项(No.2023MS325)和四川省科技厅重点研发项目(No.2023YFS0324)资助 （No.2023MS325）
