军事医学2026，Vol.50Issue(2)：124-129,6.DOI:10.7644/j.issn.1674-9960.2025-00159
人源肺类器官构建及其应用进展
Advances in construction and applications of human lung organoids
摘要
Abstract
Organoids are three-dimensional tissue structures derived from stem cells.In recent years,significant progress has been made in the culture technology of human lung organoids.This technology can create three-dimensional tissue structures that can recapitulate the architecture and function of the human lung via stage-specific induction of directed differentiation among stem cells or specialized progenitor cells.As a powerful tool for research,this technology allows in-depth investigation into lung development,provides mechanistic insights into pulmonary diseases,and accelerates the discovery of drugs.This review summarizes the latest progress in the generation of human lung organoids from adult stem cells,embryonic stem cells,and induced pluripotent stem cells in general and what needs to be optimized in current culture systems in particular,such as the development of organoid models that can accurately reproduce the distal lung architecture.In addition,the article outlines the applications of human lung organoids in pulmonary disease research,cancer drug screening,and regenerative medicine while opportunities and future applications of this promising technology are also predicted.关键词
人源肺类器官/人诱导多能干细胞/类器官Key words
human lung organoids/human induced pluripotent stem cells/organoids分类
生物科学引用本文复制引用
王一迪,李晓彤,王洪伟,朱恒..人源肺类器官构建及其应用进展[J].军事医学,2026,50(2):124-129,6.基金项目
国家自然科学基金项目(82372373) （82372373）
