军事医学2026，Vol.50Issue(2)：136-141,6.DOI:10.7644/j.issn.1674-9960.2025-00012
血脑屏障穿透肽的研究进展
Research advances in blood-brain barrier-penetrating peptides
摘要
Abstract
As more peptide drugs are increasingly entering the market,cell-penetrating peptides(CPPs)have attracted much attention due to their low toxicity,high target specificity and tolerability.CPPs targeting the central nervous system are able to transport therapeutic cargoes across the blood-brain barrier(BBB),offering novel strategies for treating the central nervous system(CNS)disorders,including Alzheimer's disease,Parkinson's disease,brain tumors,and neurotropic viral infections.This review summarizes the structural characteristics of blood-brain barrier-penetrating peptides,elucidates their mechanisms of cellular internalization,and outlines their applications in the treatment of CNS diseases.关键词
多肽/血脑屏障/中枢神经系统疾病Key words
peptides/blood-brain barrier/central nervous system disorders分类
医药卫生引用本文复制引用
吴灵莉,贾彩云,肖鹤..血脑屏障穿透肽的研究进展[J].军事医学,2026,50(2):136-141,6.基金项目
国家自然科学基金面上项目(31771010) （31771010）
