临床误诊误治2026，Vol.39Issue(6)：21-25,5.DOI:10.3969/j.issn.1002-3429.2026.06.004
乳腺原发淋巴瘤误诊为乳腺癌原因分析及鉴别诊断
Causes of misdiagnosis of primary breast lymphoma as breast cancer and differential diagnosis
张振宇 1刘政锐 1李超 2王福凯 2田照坤 2刘晓宇 2于志勇2
作者信息
- 1. 山东第一医科大学(山东省医学科学院),济南 250117||山东省肿瘤医院(山东第一医科大学附属肿瘤医院)乳腺中心乳腺外科三病区,济南 250117
- 2. 山东省肿瘤医院(山东第一医科大学附属肿瘤医院)乳腺中心乳腺外科三病区,济南 250117
- 折叠
摘要
Abstract
Objective To investigate the causes of misdiagnosis of primary breast lymphoma(PBL)as breast cancer and essential points for differential diagnosis.Methods A retrospective analysis was conducted on the clinical data of 4 patients with PBL misdiagnosed as breast cancer who were admitted to the hospital from April 2022 to October 2024.Results All of the 4 patients with PBL visited the hospital due to breast masses and were initially diagnosed as breast cancer through physical examination and relevant examinations,including 2 cases of left-sided breast cancer,1 case of left-sided breast cancer with left axillary lymph node metastasis,and 1 case of right-sided breast cancer.All 4 patients underwent surgical treatment and were diagnosed with PBL by postoperative pathology and immunohistochemistry.Among them,there were 3 cases of stage II B-cell non-Hodgkin lymphoma and 1 case of stage III.The time of misdiagnosis ranged from 5 to 40 d,with an average of(16.36±2.89)d.Patients were given adjuvant radiotherapy and chemotherapy after surgery.The patients were followed up for 3-22(11.69±2.30)months.Of them,3 patients survived,while 1 patient died after recurrence at 1 year postoperatively.Conclusion PBL lacks specific clinical manifestations,and related medical examination results are complex,making it prone to misdiagnosis as breast cancer.It is recommended to enhance clinical recognition of PBL.Comprehensive analysis combining medical history,physical examination,and relevant laboratory and imaging findings should be conducted during diagnosis,along with careful differential diagnosis.Timely breast mass biopsy with pathological and immunohistochemical examinations should be conducted for suspicious cases to reduce the misdiagnosis rate.关键词
乳腺原发淋巴瘤/误诊/乳腺肿瘤/鉴别诊断/病理学/免疫组织化学Key words
primary breast lymphoma/misdiagnosis/breast cancer/differential diagnosis/pathology/immunohistochemistry引用本文复制引用
张振宇,刘政锐,李超,王福凯,田照坤,刘晓宇,于志勇..乳腺原发淋巴瘤误诊为乳腺癌原因分析及鉴别诊断[J].临床误诊误治,2026,39(6):21-25,5.
