中国临床保健杂志2026，Vol.29Issue(1)：122-126,5.DOI:10.3969/J.issn.1672-6790.2026.01.021
皮肤晚期糖基化蛋白产物测定在糖尿病肾脏病诊断中的价值
Value of skin advanced glycation end products determination for screening diabetic kidney disease
摘要
Abstract
Objective To determine the diagnostic value and optimal cut-off value of skin advanced glycation end products(AGE)determination for screening diabetic kidney disease(DKD).Methods We conducted a retrospective cross-sectional study.A total of 141 inpatients with type 2 diabetes mellitus(T2DM)admitted to the endocrinology department of a tertiary hospital in Anhui Province from January to May 2025 were selected.General information was collected using a self-designed questionnaire,and AGE determination,serological and urine-related index determination were conducted for the patients.Patients were divided into DKD group and simple T2DM group acorrding to the UACR.Based on the sensitivity and specificity of each point on the Receiver Operating Characteristic curve(ROC)and the YouDen Index,the optimal cut-off value for AGE screening of DKD was determined.Results Among the 141 T2DM patients,the prevalence of DKD was 41.8％.The age,duration of diabetes,urine albumin(UALB),and AGE of the DKD group were significantly higher than those of the simple T2DM group(all P＜0.05).The AUC of AGE for screening DKD was 0.680(P＜0.001),and the optimal cut-off value was 82.1 AU(sensitivity:67.8％,specificity:64.4％).The AGE level of diabetic patients over 60 years old[(87.28±12.93)AU]was significantly higher than that of the population under 60 years old[(76.47±11.83)AU],P＜0.001;the AGE[(85.56±12.49)AU]]in patients with diabetes for ≥5 years was significantly higher than that in the population with a disease duration of＜5 years[(72.65±12.06)AU],P＜0.001.For diabetic patients with a duration of diabetes of ≥5 years,the optimal cut-off value of AGE for screening DKD was 80.5 AU(sensitivity:78.4％,specificity:55.4％).Conclusions Detecting skin AGE can effectively predict the development of DKD in T2DM patients,especially for those aged over 60 or with a disease duration of ≥5 years.关键词
糖尿病肾脏病/糖基化/皮肤生理学现象/诊断技术,内分泌Key words
Diabetic kidney disease/Glycosylation/Skin physiological phenomena/Diagnostic techniques,endocrine引用本文复制引用
姚红萍,李玉华,满慧慧,黄斌,程欢欢..皮肤晚期糖基化蛋白产物测定在糖尿病肾脏病诊断中的价值[J].中国临床保健杂志,2026,29(1):122-126,5.基金项目
国家自然科学基金项目(82501013) National Natural Science Foundation of China(82501013) （82501013）
