辽宁中医药大学学报2026，Vol.28Issue(4)：66-71,6.DOI:10.13194/j.issn.1673-842X.2026.04.011
中药药对治疗阿尔茨海默病药理作用研究
Research on Pharmacological Effect of Chinese Herb Pairs in Treatment of Alzheimer's Disease
摘要
Abstract
Alzheimer's disease(AD)is a multifactorial neurodegenerative disease with progressive brain dysfunction.Its incidence rate is increasing year by year,and there is no effective treatment at present,which brings a heavy burden to patients and their families.As the beginning of compound prescriptions,although the composition of herb pairs is simple,they have the basic characteristics of Chinese medicine compatibility,play the role of synergistic enhancement,toxicity reduction,and expand the scope of clinical application.It is now widely used in anti-AD treatment.Many pharmacological studies have confirmed that drug pairs play an anti-AD role mainly through inhibiting the production of Aβ,preventing tau protein hyperphosphorylation,reducing inflammatory response,improving synaptic plasticity,anti-oxidation,anti-apoptosis,regulating neurotransmitters and other pathways.This article combs through the relevant literature on the pharmacological effect of herb pairs in the treatment of AD,and based on the etiology and pathogenesis of AD,summarizes and analyzes the compatibility theory,network pharmacology and experimental research of commonly used herb pairs,and sorts out 14 drug pairs with relatively in-depth research,to establish a theoretical basis for AD treatment using herb pairs and provide a reference for clinical drug use and new drug development.关键词
阿尔茨海默病/中药药对/药理作用Key words
Alzheimer's disease/Chinese herb pairs/pharmacological effect分类
医药卫生引用本文复制引用
刘畅,于涵,崔华,程光宇,程为平..中药药对治疗阿尔茨海默病药理作用研究[J].辽宁中医药大学学报,2026,28(4):66-71,6.基金项目
黑龙江省自然科学基金项目(LH2021H091) （LH2021H091）
黑龙江省第二批省级名中医专家传承工作室建设项目(黑中医药科教函[2021]24号) （黑中医药科教函[2021]24号）
黑龙江中医药大学"双一流"中西医结合学科发展助力基金项目(HLJSYL1006) （HLJSYL1006）
