国际眼科杂志2026，Vol.26Issue(4)：594-599,6.DOI:10.3980/j.issn.1672-5123.2026.4.07
巩膜重塑在近视防治中的研究进展
Research progress on scleral remodeling in the prevention and control of myopia
摘要
Abstract
Myopia is a highly prevalent refractive error worldwide,with scleral remodeling accompanying excessive axial elongation being one of its core pathological features.As the crucial outer layer responsible for maintaining eyeball morphology and biomechanical stability,the sclera plays a decisive role in the pathogenesis and progression of myopia through abnormal alterations in its cellular components,extracellular matrix(ECM)metabolism,and regulatory networks.This review systematically summarizes recent research advances in scleral remodeling.It focuses on elucidating,from cellular and molecular perspectives,the mechanisms by which dysfunction of scleral fibroblasts,dysregulation of ECM metabolism(e.g.,decreased collagen content,disrupted MMP-2/TIMP-2 balance),and complex regulatory networks involving multiple signaling pathways such as TGF-β,Wnt/β-catenin,and MAPK drive scleral thinning and reduced mechanical strength.Concurrently,the review provides a comprehensive analysis of the potential roles and existing controversies regarding factors like inflammatory responses and novel regulatory axes(e.g.,FOXM1/METTL3/APOA1)in scleral remodeling.Furthermore,it discusses the current research status and application prospects of sclera-targeted intervention strategies(e.g.,modulating specific pathways,supplementing exogenous factors),aiming to provide a theoretical basis and directional reference for a deeper understanding of myopia pathogenesis and the development of new prevention and treatment approaches.关键词
巩膜重塑/近视/细胞与分子机制/信号通路Key words
scleral remodeling/myopia/cellular and molecular mechanisms/signaling pathways引用本文复制引用
郜若山,祝悦,唐月瑶,刘雪,颉瑞萍..巩膜重塑在近视防治中的研究进展[J].国际眼科杂志,2026,26(4):594-599,6.基金项目
国家自然科学基金(No.82560960) （No.82560960）
甘肃省中医药科研课题(No.GZKP-2023-14,GZKG-2024-50) （No.GZKP-2023-14,GZKG-2024-50）
甘肃中医药大学研究生创新创业资助项目(No.2026CXCY-277) National Natural Science Foundation of China(No.82560960) （No.2026CXCY-277）
Traditional Chinese Medicine Research Project of Gansu Province(No.GZKP-2023-14,GZKG-2024-50) （No.GZKP-2023-14,GZKG-2024-50）
Innovation and Entrepreneurship Funding Project for Postgraduates,Gansu University of Chinese Medicine(No.2026CXCY-277) （No.2026CXCY-277）
