国际眼科杂志2026，Vol.26Issue(4)：651-656,6.DOI:10.3980/j.issn.1672-5123.2026.4.17
木犀草素在眼科疾病中的研究进展
Research progress of luteolin in ocular diseases
摘要
Abstract
Natural flavonoids have attracted considerable attention owing to their favorable biosafety profiles and multiple pharmacological properties in recent years.Luteolin,a representative flavonoid compound,exhibits anti-inflammatory,antioxidant,anti-angiogenic,and neuroprotective effects in multiple ocular disease models by modulating key signaling pathways,including NF-κB,PI3K/Akt,Nrf2/HO-1,and AGE-RAGE.Accumulating experimental evidence supports the potential application of luteolin in various ocular diseases,including corneal and ocular surface diseases,inflammatory eye diseases,glaucoma,cataract,diabetic retinopathy,and age-related macular degeneration.However,clinical evidence remains limited.This review systematically summarizes research progress on luteolin in ocular diseases over the past five years,analyzes its molecular mechanisms and therapeutic potential,and discusses future directions,so as toprovide a theoretical basis for clinical translation.关键词
木犀草素/眼科疾病/抗氧化/抗炎Key words
luteolin/ocular diseases/antioxidation/anti-inflammation引用本文复制引用
贺思捷,郭滨,蒋文君..木犀草素在眼科疾病中的研究进展[J].国际眼科杂志,2026,26(4):651-656,6.基金项目
山东省自然科学基金项目(No.ZR2020MH393) （No.ZR2020MH393）
山东中医药大学临床科研专项(No.LCKY202432) Natural Science Foundation of Shandong Province(No.ZR2020MH393) （No.LCKY202432）
Clinical Research Special Project of Shandong University of Traditional Chinese Medicine(No.LCKY202432) （No.LCKY202432）
