南京中医药大学学报2026，Vol.42Issue(3)：323-329,7.DOI:10.14148/j.issn.1672-0482.2026.0323
态靶辨治理论指导下的中医个体化诊疗模式创新
Innovative Model of Personalized Diagnosis and Treatment in Traditional Chinese Medicine Under the Guidance of State-Target Differentiation and Treatment Theory
摘要
Abstract
Individualized treatment based on syndrome differentiation is a defining feature of clinical traditional Chinese medicine(TCM).To adapt to shifts in the disease spectrum and meet modern clinical demands,successive exploratory models—such as disease-syndrome combination and integrated macro-micro syndrome differentiation—could not to fundamentally resolve the core bottleneck in‑herent in traditional individualized treatment,characterized as"strength in individual cases but weakness in population-level patterns;strength in cross-sectional assessment but weakness in longitudinal insight;and strength in state regulation but weakness in targeted in‑tervention".The"state-target differentiation and treatment"theory proposed by Professor Tong Xiaolin centers on a dual reconstruc‑tion:of the modern TCM diagnostic framework and the modern TCM materia medica system.Through establishing an integrated theo‑retical framework of"disease–category–stage–state–syndrome–target",standardizing the full-process clinical pathway of diagnosis–intervention–management–evaluation,and leveraging clinical and basic research to guide targeted drug selection based on extracted population commonalities,the theory systematically accomplishes the pathway reconstruction of the TCM individualized treatment model.This model achieves simultaneous consideration of state regulation and targeted intervention,and harmonizes population com‑monalities with individual precision,thereby consolidating the theoretical and practical foundation for full-cycle disease prevention and control with TCM and for the explication of TCM modernization.关键词
个体化诊疗/态靶辨治/模式创新/全周期管理/仝小林/病证结合/宏观辨证/微观辨证Key words
individualized diagnosis and treatment/state-target differentiation and treatment/model innovation/full-cycle manage‑ment/Tong Xiaolin/disease-syndrome combination/macroscopic syndrome differentiation/microscopic syndrome differentiation分类
医药卫生引用本文复制引用
薛崇祥,谢伟楠,王思成,王亚运,仝小林,王涵..态靶辨治理论指导下的中医个体化诊疗模式创新[J].南京中医药大学学报,2026,42(3):323-329,7.基金项目
国家自然基金委-中国科学院联合项目资助中西医结合创新范式战略研究(XK2023SMC003) （XK2023SMC003）
中国科协青年人才托举工程项目[CACM-(2024-QNRC1-01)] （2024-QNRC1-01）
中国中医科学院研究生教育教学改革研究项目(JG24-01) （JG24-01）
北京中医药大学壶天客座教授科研启动经费资助项目(2023-XJ-KYQD-006) （2023-XJ-KYQD-006）
长春中医药大学附属医院医学中心建设基金项目(DXZX-02-01) （DXZX-02-01）
