南京中医药大学学报2026，Vol.42Issue(3)：336-345,10.DOI:10.14148/j.issn.1672-0482.2026.0336
基于癌毒驱动-态靶同调探讨肝癌伏邪-伏毒-癌毒病机演变规律与辨治策略
Exploring the Pathogenesis Evolution and Differentiation and Treatment Strategies of"Latent Pathogen-Latent Toxin-Cancer Toxin"in Hepatocellular Carcinoma Based on"Cancer Toxin-Driven and State-Target Synergy"Theory
摘要
Abstract
Primary hepatocellular carcinoma is one of the most prevalent malignancies worldwide,characterized by complex etiol‑ogy,rapid progression,and a serious threat to human health.Traditional Chinese Medicine(TCM)attributes the development of hepato‑cellular carcinoma to the interplay of stasis,toxin accumulation,and deficiency.In recent years,the"cancer toxin"theory has gained increasing attention;however,its dynamic formation and evolution remain inadequately elucidated.Based on classical TCM etiology and pathogenesis theory,integrated with modern diagnostic and therapeutic concepts,this study proposes an innovative"cancer toxin-driven and state-target synergy"treatment system.A three-stage dynamic model of pathogenesis transformation-latent pathogen,la‑tent toxin,and cancer toxin-was established to clarify the progression from damp-heat epidemic toxin latency to phlegm-stasis tumor formation and finally to toxin-fire-induced carcinogenesis.Correspondingly,a phased differentiation treatment strategy of"modulating internal state and consolidating the foundation,targeting and removing toxins"is proposed,aiming for comprehensive regulation throughout the disease course:prevention before onset,suppression during development,and stabilization amidst progression.This pa‑per systematically evaluates the efficacy of Shipi Xiaoji Formula-a TCM formula developed under this framework-through analysis of its formulation rationale,experimental mechanism verification,and clinical therapeutic synergy.The study provides theoretical and practical support for TCM-based differentiation and treatment of hepatocellular carcinoma,with promising implications for clinical ap‑plication.关键词
原发性肝癌/癌毒驱动/态靶同调/伏邪/伏毒/癌毒/实脾消积方Key words
primary hepatocellular carcinoma/cancer toxin driven/state-target synergy/latent pathogen/latent toxin/cancer toxin/Shipi Xiaoji Formula分类
医药卫生引用本文复制引用
杨仁义,吴玲,张婧婷,翦慧颖,童天昊,曾普华..基于癌毒驱动-态靶同调探讨肝癌伏邪-伏毒-癌毒病机演变规律与辨治策略[J].南京中医药大学学报,2026,42(3):336-345,10.基金项目
国家重大疑难疾病中西医临床协作项目(202497) （202497）
湖南省自然科学基金重点项目(2025JJ30038) （2025JJ30038）
国家中医药管理局中西医结合与少数民族医药司项目(ZXYJHMZYYS2024-034) （ZXYJHMZYYS2024-034）
湖南省卫生健康高层次人才重大科研专项(R2023081) （R2023081）
国家中医药管理局青年岐黄学者支持项目(国中医药人教函[2020]218号) （国中医药人教函[2020]218号）
