南京中医药大学学报2026，Vol.42Issue(3)：358-364,7.DOI:10.14148/j.issn.1672-0482.2026.0358
基于"肺-咽-肾"轴探讨儿童紫癜性肾炎的病机与治疗
Explore the Pathogenesis and Treatment of Purpuric Nephritis in Children Based on the"Lung-Pharynx-Kidney"Axis
摘要
Abstract
Henoch-Schonlein purpura nephritis(HSPN)is the most common secondary glomerular disease in children,often caused by respiratory infections complicated by tonsillitis.Abnormal mucosal immunity leads to the production of large amounts of galactose-deficient IgA1,forming immune complexes that deposit in the kidneys,causing the disease to prolong and progress chroni‑cally.The lung,pharynx,and kidney are interconnected and functionally linked,forming the"lung-pharyngeal-kidney"axis,which plays a crucial role in the pathogenesis and progression of HSPN.This article reveals the theoretical connotation of the"lung-pharynx-kidney"axis in HSPN,explores the pathogenesis of HSPN from the perspective of the"lung-pharynx-kidney"axis,and discusses treat‑ment in three stages.In the lung-pharynx stage,six exogenous pathogenic factors cause heat to accumulate in the throat;treatment fo‑cuses on dispelling wind and releasing the exterior,clearing heat and benefiting the throat.In the pharynx-kidney stage,heat enters the nutrient blood and travels along the meridians to the kidneys;treatment focuses on clearing the nutrient level and cooling the blood,resolving stasis and unblocking the meridians.In the kidney deficiency stage,there is kidney yin deficiency,upward scorching of defi‑cient fire,or insufficient kidney yang and inadequate lung guard;treatment focuses on nourishing kidney yin,guiding fire back to its source,or warming and tonifying kidney yang and enhance lung guard.关键词
"肺-咽-肾"轴/紫癜性肾炎/儿童/扁桃体炎/黏膜免疫异常/半乳糖缺陷型IgA1/分期辨治Key words
"lung-pharynx-kidney"axis/Henoch-Schonlein purpuric nephritis/children/tonsillitis/mucosal immune abnormali‑ties/galactose-deficient IgA1/staged differentiation and treatment分类
医药卫生引用本文复制引用
张霞,许济祥,张帅,徐婷婷,任献青,丁樱..基于"肺-咽-肾"轴探讨儿童紫癜性肾炎的病机与治疗[J].南京中医药大学学报,2026,42(3):358-364,7.基金项目
国家自然科学基金面上项目(82474568) （82474568）
中华中医药学会青年求实项目(2023-QNQS-06,2025-QSDXWT-04) （2023-QNQS-06,2025-QSDXWT-04）
河南省中青年学科带头人培养项目(豫卫人[2022]26号) （豫卫人[2022]26号）
河南省科技研发计划联合基金项目(222301420078) （222301420078）
河南省自然科学基金面上项目(222300420488) （222300420488）
