神经病学与神经康复学杂志2026，Vol.22Issue(1)：7-11,5.DOI:10.12022/jnnr.2025-0241
器官移植后运动障碍的临床诊治进展
Advances in clinical management of post-transplant movement disorders
摘要
Abstract
Movement disorders are one of common neurological complications following solid organ transplantation.They encompass various clinical manifestations,including tremor,myoclonus,and chorea,which significantly impact patients'quality of life.Neurological complications following solid organ transplantation are generally observed at a relatively high overall incidence,with variations across different types of organ transplants.Among these,neurological complications are relatively more common after liver transplantation,which is associated with multiple factors such as hepatic encephalopathy.Although the underlying mechanisms remain incompletely understood,these complications are thought to arise from neurotoxicity from immunosuppressive drugs,metabolic disturbances,and surgical factors.Post-transplant movement disorders often coexist with multiple symptoms,necessitating an active search for underlying causes,ruling out possibilities such as ischemic-hypoxic encephalopathy,infection,or stroke.If movement disorders occur in isolation,the neurotoxicity of medications,such as immunosuppressive agents,should be considered first.Treatment involves etiological management(optimizing the immunosuppressive regimen)and symptomatic therapy(such as antiepileptic drugs,clonazepam,or botulinum toxin injections).With timely intervention,most cases achieve favorable outcomes with a good prognosis.This review focuses on the epidemiology,clinical manifestations,associated symptoms,diagnosis and differential diagnosis,treatment,and prognosis of involuntary movements following liver,kidney,and heart transplantation,aiming to serve as a clinical reference.关键词
器官移植/震颤/肌阵挛/泵后舞蹈症Key words
Organ transplantation/Tremor/Myoclonus/Post-pump chorea引用本文复制引用
赵乐雅,戴若莲,JEONG Seong Ho,王刚..器官移植后运动障碍的临床诊治进展[J].神经病学与神经康复学杂志,2026,22(1):7-11,5.基金项目
国家自然科学基金(82271462) National Natural Science Foundation of China(82271462) （82271462）
