神经病学与神经康复学杂志2026，Vol.22Issue(1)：65-69,5.DOI:10.12022/jnnr.2025-0287
阿尔茨海默病相关抑郁症状与认知障碍的研究进展
Research progress on depressive symptoms and cognitive impairment related to Alzheimer's disease
摘要
Abstract
Alzheimer's Disease(AD)is often accompanied by various neuropsychiatric symptoms,among which depressive symptoms are particularly common and may even appear in the preclinical stage.This paper systematically reviews the complex relationship between depressive symptoms(including subsyndromal symptomatic depression)and AD-related cognitive impairment,with a focus on the potential role of AD-characteristic brain regions such as the hippocampus.Current evidences have suggested that depressive symptoms may accelerate the progression of cognitive decline through various pathways,such as promoting brain atrophy of key brain regions,affecting neuroplasticity,and exacerbating the deposition of amyloid β-protein(Aβ).Future research should further integrate multimodal neuroimaging techniques with non-invasive biomarkers,in order to provide new theoretical basis and clinical targets for early identification and precise intervention of AD in high-risk populations.关键词
阿尔茨海默病/抑郁症状/亚综合征性抑郁/认知障碍/海马Key words
Alzheimer's disease/Depressive symptoms/Subsyndromal symptomatic depression/Cognitive impairment/Hippocampus引用本文复制引用
荆晨曦,巴茂文..阿尔茨海默病相关抑郁症状与认知障碍的研究进展[J].神经病学与神经康复学杂志,2026,22(1):65-69,5.基金项目
国家自然科学基金(81571234) National Natural Science Foundation of China(81571234) （81571234）
