世界科学技术-中医药现代化2026，Vol.28Issue(3)：960-967,8.DOI:10.11842/wst.20250519008
基于中西医临床病证特点的退行性腰椎管狭窄症动物模型分析
Analysis of Animal Models of Degenerative Lumbar Spinal Stenosis Based on Characteristics of Clinical Symptoms of Chinese and Western Medicine
摘要
Abstract
Degenerative lumbar spinal stenosis(DLSS)is a common disease in middle-aged and elderly people with lumbar and leg pain and activity limitation,and the establishment of a standardized animal model of DLSS with Chinese and Western clinical characteristics is of great significance to the analysis of the disease.The article summarizes and analyzes the advantages and disadvantages of the existing animal models of DLSS and the degree of agreement with the clinic,with reference to the etiology and clinical diagnostic standards of Chinese and Western medicine.The current DLSS models were found to exhibit higher clinical characteristics with Western medicine than with traditional Chinese medicine.Among all DLSS models,the lysophosphatidic acid-induced model demonstrated the highest clinical characteristics with both Western and traditional Chinese medicine.At the present stage,the animal model of DLSS should be further improved according to the contents of TCM symptoms,and a composite model with the dynamic pathogenesis of the"deficiency in origin and excess in superficiality"should be constructed through the cross-validation of TCM and Western medicine pathologic mechanisms.In the future,we should focus on promoting the construction of accurate models for the objective evaluation of Chinese medicine symptoms and the combination of Chinese and Western medicine treatments.关键词
退行性腰椎管狭窄症/中西医/病证特点/动物模型/临床吻合度/模型分析Key words
Degenerative lumbar spinal stenosis/Traditional Chinese and Western medicine/Disease characteristics/Animal model/Clinical anastomosis/Model analysis分类
医药卫生引用本文复制引用
张硕,曹帅,董春科,韦竑宇,刘清泉..基于中西医临床病证特点的退行性腰椎管狭窄症动物模型分析[J].世界科学技术-中医药现代化,2026,28(3):960-967,8.基金项目
首都临床特色诊疗技术研究及转化应用项目(Z221100007422122):国产人工颈椎间盘研发的基础与临床研究,负责人:韦竑宇. （Z221100007422122）
