实用心脑肺血管病杂志2026，Vol.34Issue(5)：31-35,5.DOI:10.12114/j.issn.1008-5971.2026.00.091
青海地区阻塞性睡眠呼吸暂停相关性高血压患者颈动脉粥样硬化的危险因素分析
Risk Factors of Carotid Atherosclerosis in Patients with Obstructive Sleep Apnea-Related Hypertension in Qinghai
摘要
Abstract
Objective To investigate the risk factors of carotid atherosclerosis in patients with obstructive sleep apnea(OSA)-related hypertension in Qinghai.Methods A total of 169 patients with OSA-related hypertension admitted to Qinghai Special Hospital for Cardio-Cerebrovascular Diseases from March 2023 to March 2024 were selected as the research subjects.The general information,laboratory inspection indicators,sleep monitoring indicators,and dynamic blood pressure monitoring indicators on admission of patients were collected,and patients were divided into control group(normal carotid artery,n=57),early subclinical atherosclerosis(eSA)group(eSA,n=60)and plaque group(carotid atherosclerotic plaque formation,n=52)according to carotid atherosclerosis.Multiple Logistic regression analysis was used to explore the risk factors of carotid atherosclerosis in patients with OSA-related hypertension.Results The age in the eSA group was older than that in the control group,the age in the plaque group was older than that in the control group and the eSA group(P<0.05).The apolipoprotein B(ApoB),malondialdehyde(MDA),apnea-hypopnea index(AHI),oxygen desaturation index(ODI),24-hour average systolic blood pressure,nighttime average systolic blood pressure,and nighttime systolic blood pressure in the plaque group were higher than those in the control group,the nighttime decrease rates of systolic blood pressure and diastolic blood pressure were lower than those in the control group,and the lowest blood oxygen saturation was lower than that in the control group and eSA group(P<0.05).Multiple Logistic regression analysis showed that increased age[OR=1.064,95%CI(1.016-11.113)]was a risk factor for eSA in patients with OSA-related hypertension(P<0.05);increased age[OR=1.134,95%CI(1.072-1.200)],increased ApoB[OR=10.766,95%CI(1.172-98.874)],increased MDA[OR=1.920,95%CI(1.233-3.014)]were risk factors for carotid atherosclerosis plaque formation in patients with OSA-related hypertension(P<0.05).Conclusion Increased age is a risk factor for eSA in patients with OSA-related hypertension;increased age,increased ApoB and increased MDA are risk factors for carotid atherosclerosis plaque formation in patients with OSA-related hypertension.关键词
高血压/睡眠呼吸暂停,阻塞性/动脉粥样硬化/危险因素Key words
Hypertension/Sleep apnea,obstructive/Atherosclerosis/Risk factors分类
医药卫生引用本文复制引用
王银梅,汪晓洲..青海地区阻塞性睡眠呼吸暂停相关性高血压患者颈动脉粥样硬化的危险因素分析[J].实用心脑肺血管病杂志,2026,34(5):31-35,5.基金项目
2022年度青海省"昆仑英才·高端创新创业人才"项目培养领军人才 （）
