实用心脑肺血管病杂志2026，Vol.34Issue(5)：47-51,5.DOI:10.12114/j.issn.1008-5971.2025.00.277
非高密度脂蛋白胆固醇/高密度脂蛋白胆固醇比值与中老年人发生全因死亡的关系:基于CHARLS的横断面研究
Relationship between NHHR and All-Cause Death in Middle-Aged and Elderly People:a Cross-Sectional Study Based on CHARLS
摘要
Abstract
Objective To discuss the relationship between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio(NHHR)and all-cause death in middle-aged and elderly people based on the China Health and Retirement Longitudinal Study(CHARLS).Methods The data of 10 318 middle-aged and elderly people from the 2011,2013,2015,and 2018 datasets of CHARLS.Clinical data of the middle-aged and elderly people in the 2011 CHARLS data were collected,the occurrence of all-cause mortality of the middle-aged and elderly people in the 2013,2015,2018 CHARLS data was collected,and middle-aged and elderly people were divided into the death group and the non-death group according to the occurrence of all-cause death.Restricted cubic spline(RCS)plot was drawn to analyze the dose-response relationship between NHHR and all-cause death risk in middle-aged and elderly people.Multivariate Cox proportional hazards regression analysis was used to discuss the relationship between NHHR and all-cause death in middle-aged and elderly people.Results Among the 10 318 cases of middle-aged and elderly people,1 077 cases occurred all-cause death(accounting for 10.44%).There were significant differences in age,gender,education level,marital status,incidence of smoking,drinking situation,incidence of hypertension,incidence of diabetes,uric acid(UA),TG,TC,fasting plasma glucose(FPG),and glycated hemoglobin(HbA1c)between the death group and the non-death group(P<0.05).The RCS plot analysis results indicated that the association between NHHR and all-cause death risk in middle-aged and elderly people showed a U-shaped double inflection point(Pfor overall=0.003,Pfor nonlinear<0.001).The point of lowest risk was 3.71,and the risk inflection points were 2.82 and 4.83 respectively.The NHHR was divided into the four subgroups:<2.82(n=5 137),2.82-3.71(n=2 440),3.72-4.83(n=1 632),and>4.83(n=1 109).Multivariate Cox proportional hazards regression analysis results showed that NHHR<2.82[HR=0.80,95%CI(0.68-0.96)]was a protective factor of all-cause death in middle-aged and elderly people,NHHR>4.83[HR=1.06,95%CI(1.02-1.11)]was its risk factor(P<0.05).Conclusion NHHR<2.82 is a protective factor of all-cause death in middle-aged and elderly people,and NHHR>4.83 is its risk factor.关键词
胆固醇,HDL/全因死亡/中老年人/非高密度脂蛋白胆固醇/高密度脂蛋白胆固醇比值/中国健康与养老追踪调查Key words
Cholesterol,HDL/All-cause death/Middle-aged and elderly people/NHHR/China Health and Retirement Longitudinal Study分类
医药卫生引用本文复制引用
刘硕,郝杰,方奎,王锐..非高密度脂蛋白胆固醇/高密度脂蛋白胆固醇比值与中老年人发生全因死亡的关系:基于CHARLS的横断面研究[J].实用心脑肺血管病杂志,2026,34(5):47-51,5.基金项目
国家自然科学基金青年科学基金项目(82103450) （82103450）
