时珍国医国药2026，Vol.37Issue(5)：913-923,11.DOI:10.70976/j.1008-0805.SZGYGY-2026-0517
中医药调控Keap1/Nrf2/ARE信号通路治疗阿尔茨海默病的研究进展
Research progress of traditional Chinese medicine in regulating the Keap1/Nrf2/ARE signaling pathway in the treatment of Alzheimer's disease
摘要
Abstract
Alzheimer's disease(AD)is a chronic neurodegenerative disease with limited treatment options.Traditional Chinese medi-cine(TCM)has demonstrated potential in alleviating clinical symptoms and delaying disease progression.The therapeutic mechanisms of TCM are closely associated with the regulation of the Keap1)/Nrf2/ARE signaling pathway.This review systematically summarizes the neuroprotective effects of the Keap1/Nrf2/ARE pathway in AD,which include mitigating oxidative stress,inhibiting neuroinflammation,enhancing mitochondrial function,regulating iron metabolism,suppressing apoptosis,and modulating autophagy.Furthermore,it eluci-dates how Chinese medicinal(CM)-derived active monomers,major constituents,compound formulations,and related non-pharmacological therapies exert their effects against AD through modulating this pathway.This review aims to provide a theoretical foun-dation for the clinical application of TCM and the development of novel medicinal agents for AD.关键词
Kelch样ECH相关蛋白1/核因子E2相关因子2/抗氧化反应元件/信号通路/中医药/阿尔茨海默病Key words
Keap1/Nrf2/ARE/Signaling pathway/Traditional Chinese medicine/Alzheimer's disease分类
医药卫生引用本文复制引用
包璇,金华,司美龙,张泽祥,雍芸,杜婕,刘杰..中医药调控Keap1/Nrf2/ARE信号通路治疗阿尔茨海默病的研究进展[J].时珍国医国药,2026,37(5):913-923,11.基金项目
国家自然科学基金地区项目(82160886) （82160886）
甘肃省重点人才项目(2023RCXM28) （2023RCXM28）
甘肃省省级科技计划项目(23JRRA1524) （23JRRA1524）
