苏州科技大学学报（自然科学版）2026，Vol.43Issue(1)：31-41,11.DOI:10.12084/j.issn.2096-3289.2026.01.005
超声响应的MnCeFe层状三金属氢氧化物用于耐药菌感染治疗的研究
Ultrasound-responsive MnCeFe-layered trimetal hydroxide for the treatment of drug-resistant bacterial infections
摘要
Abstract
Multi-drug resistant(MDR)bacterial infections pose significant clinical challenges due to dense biofilm formation and the complex pathological microenvironment in infected areas.Ultrasound-responsive nanomaterials have shown promising potential in treating drug-resistant infections owing to their non-invasive nature,precise tar-geting of infected areas,and controllable generation of reactive oxygen species(ROS)to disrupt bacterial structures.In this study,we developed an ultrasound-responsive MnCeFe-layered trimetal hydroxide(MnCeFe LDH)nanoplat-form for effective treatment of drug-resistant bacterial infections.The MnCeFe LDH,synthesized via an optimized co-precipitation method,exhibited uniform size and stable dispersion.Under ultrasound irradiation,the material sig-nificantly enhanced ROS generation and glutathione depletion,with hydroxyl radicals(•OH),singlet oxygen(¹O₂),and superoxide anions(•O₂⁻)production increasing by 4.10-fold,1.75-fold,and 2.14-fold,respectively,com-pared to non-ultrasound conditions.Band structure analysis revealed that the abundant ROS generation originated from efficient redox catalytic processes among the variable valence states of Ce-Mn-Fe trimetal and that ultrasound-induced polarization effects promoted electron-hole separation and electron transfer.Vitro experiments demonstrated that the material achieved inhibition efficiencies of 93.7%and 97.3%against methicillin-resistant Staphylococcus au-reus(MRSA)and Escherichia coli ER2738 under ultrasound activation,along with biofilm degradation rates of 74.0%and 82.9%,respectively,indicating near-complete eradication of drug-resistant bacteria.This study pro-vides a novel and efficient nano-catalytic strategy for combating MDR bacterial infections.关键词
层状三金属氢氧化物/声动力治疗/多重耐药菌/活性氧/生物膜降解Key words
layered trimetal hydroxide/sonodynamic therapy/multi-drug resistant bacteria/reactive oxygen spe-cies/biofilm degradation分类
化学化工引用本文复制引用
安星星,王晏玫昱,黄晓婷,陈博..超声响应的MnCeFe层状三金属氢氧化物用于耐药菌感染治疗的研究[J].苏州科技大学学报（自然科学版）,2026,43(1):31-41,11.基金项目
国家自然科学基金项目(22108187) （22108187）
江苏省自然科学基金优秀青年基金项目(BK20230073) （BK20230073）
