心脑血管病防治2026，Vol.26Issue(2)：25-28,34,5.DOI:10.3969/j.issn.1009-816x.2026.02.006
转化生长因子β1基因突变对急性心肌梗死患者经皮冠状动脉介入治疗术后再狭窄的影响
Impact of transforming growth factor β1 gene mutation on restenosis in patients with acute myocardial infarction after percutaneous coronary intervention
摘要
Abstract
Objective To investigate the impact of transforming growth factor β1(TGF-β1)gene mutation on restenosis in patients with acute myocardial infarction(AMI)after percutaneous coronary intervention(PCI).Methods A total of 120 AMI patients treated at Xingtai Central Hospital from June 2020 to June 2022 were selected as the study group,and 120 healthy individuals undergoing physical examinations at the hospital during the same period were selected as the control group.The mutation of TGF-β1 gene was compared between the two groups.According to the occurrence of in-stent restenosis after PCI,patients in the study group were further divided into a restenosis group(38 cases)and a non-restenosis group(82 cases).Medical records of the two groups were compared,and influencing factors for restenosis after PCI were analyzed using Logistic regression.Results Three genotypes were identified at the 509C/T locus of TGF-β1:CC,CT,and TT.The frequencies of the CC genotype(33.33%vs.11.67%)and the C allele(55.83%vs.38.33%)were higher in the study group than in the control group(χ2=17.131,14.750;P<0.05).Among the 120 AMI patients,38 cases had restenosis after PCI.The frequencies of the CC genotype(52.63%vs.24.39%)and the C allele(71.05%vs.48.78%)were higher in the restenosis group than in the non-restenosis group,with statistically significant differences(χ2=10.221,10.447;P<0.05).The proportions of hypertension and diabetes,as well as the levels of low-density lipoprotein cholesterol(LDL-C)and total cholesterol(TC),were higher in the restenosis group than in the non-restenosis group(χ2/t=7.408,6.213,3.159,2.416;P<0.05).Hypertension,diabetes,and the TGF-β1 CC genotype were the influencing factors for restenosis after PCI(OR=1.589,1.725,1.624;P<0.05).Conclusion AMI patients have a higher proportion of CC genotype and C allele frequency at the 509C/T locus of TGF-β1.The genotype at the 509C/T locus of TGF-β1 is correlated with restenosis after PCI,with the CC genotype increasing the risk of restenosis in AMI patients after PCI.关键词
转化生长因子β1/基因突变/急性心肌梗死/经皮冠状动脉介入治疗/再狭窄Key words
Transforming growth factor β1/Gene mutation/Acute myocardial infarction/Percutaneous coronary intervention/Restenosis引用本文复制引用
孙茹,郝晓辉,黄玲芳..转化生长因子β1基因突变对急性心肌梗死患者经皮冠状动脉介入治疗术后再狭窄的影响[J].心脑血管病防治,2026,26(2):25-28,34,5.基金项目
邢台市重点研发计划项目(2023ZC080) （2023ZC080）
