新医学2026，Vol.57Issue(3)：213-221,9.DOI:10.12464/j.issn.0253-9802.2025-0260
神经环路损伤及修复在阿尔茨海默病发病及康复中的作用及机制
The role and mechanisms of neural circuit damage and repair in the onset and recovery of Alzheimer's disease
摘要
Abstract
Alzheimer's disease(AD)is characterized by progressive cognitive decline rooted in structural and functional impairment of neural circuits.The dynamic mechanisms governing circuit pathology and repair in AD remain elusive.In this article,the injury mechanisms within core AD circuits(e.g.,hippocampo-entorhinal and Papez circuits)were systematically illustrated,highlighting the advances in their repair and reorganization.Beyond summarizing the Aβ/Tau pathology-circuit dysfunction interaction,the hypothesis that circuit abnormalities precede protein deposition was also critically examined.Furthermore,the potential and challenges of circuit-targeted interventions(e.g.,neuromodulation,etc.)in the treatment of AD were evaluated.We advocate for a precision therapeutic paradigm focused on circuit remodeling to effectively slow disease progression and promote recovery.This work provides a theoretical framework for AD circuitopathy and guides the development of targeted therapies.关键词
阿尔茨海默病/神经环路/认知功能/神经环路重塑/神经调控Key words
Alzheimer's disease/Neural circuits/Cognitive function/Circuit remodeling/Neuromodulation引用本文复制引用
杨晓枫,何小飞,左泽杰,张丽颖,邓娟,胡昔权..神经环路损伤及修复在阿尔茨海默病发病及康复中的作用及机制[J].新医学,2026,57(3):213-221,9.基金项目
国家重点研发计划(2022YFC3601200) （2022YFC3601200）
国家自然科学基金面上项目(82172546) （82172546）
