疑难病杂志2026，Vol.25Issue(3)：380-384,5.DOI:10.3969/j.issn.1671-6450.2026.03.023
衣康酸及其衍生物在脓毒症中的作用研究进展
Research progress of itaconic acid and its derivatives in sepsis
摘要
Abstract
Sepsis is multi-organ dysfunction due to a dysregulated response to infection.Due to the high morbidity,high mortality and high treatment costs,and the lack of effective treatment methods,the global medical burden has become in-creasingly serious in recent years,so it is imperative to explore the mechanism of the occurrence and development of sepsis and find new therapeutic drugs that may improve or prevent the occurrence and development of sepsis.Studies have found that itaconic acid,as a naturally occurring metabolite in immune cells,plays an important role in regulating inflammation and im-mune metabolism,and may be a very promising drug for the prevention and treatment of sepsis.This article reviews the re-search progress on the mechanism of action and efficacy of itaconic acid in the treatment of sepsis and the protection of multi-organ function,in order to provide more ideas and help for the research and treatment of sepsis.关键词
脓毒症/多器官功能障碍综合征/衣康酸/器官保护/炎性反应Key words
Sepsis/Multiple organ dysfunction syndrome/Itaconic acid/Organ protection/Inflammation分类
医药卫生引用本文复制引用
南龙腾,王聪睿,侯曼,张文凯..衣康酸及其衍生物在脓毒症中的作用研究进展[J].疑难病杂志,2026,25(3):380-384,5.基金项目
山西省自然科学基金项目(202203021221278) Natural Science Foundation of Shanxi Province(202203021221278) （202203021221278）
