中国当代儿科杂志2026，Vol.28Issue(3)：285-292,8.DOI:10.7499/j.issn.1008-8830.2503063
早产儿1～12月龄肠道菌群的动态变化
Dynamic changes in gut microbiota from 1 to 12 months of age in preterm infants
摘要
Abstract
Objective To investigate the dynamic development of gut microbiota in preterm infants during their first year after birth and to compare the microbiota profiles between preterm infants of different gestational ages.Methods In this prospective study,81 preterm infants(including 37 early preterm and 44 moderate-to-late preterm infants)and 26 full-term infants were enrolled from Shenzhen Bao'an Women and Children's Hospital between January 2021 and September 2022.Fecal samples were collected at 1,6,and 12 months of age.16S rRNA sequencing was conducted,followed by comprehensive bioinformatics analysis.Results The alpha diversity indices of the gut microbiota in preterm infants increased significantly from 1 to 12 months of age(P<0.001).With increasing age,the relative abundances of Clostridium,Streptococcus,Klebsiella,and Staphylococcus decreased,whereas those of Bifidobacterium,Lactobacillus,and Bacteroides increased.At 1 month of age,significant disparities were observed in alpha diversity,beta diversity,and taxonomic abundances among different gestational age groups.Specifically,Clostridium and Aeromonas were enriched in early preterm infants.By 12 months of age,no significant differences in these microbial metrics were detected across the gestational age groups(P>0.05).Conclusions The gut microbiota of preterm infants becomes progressively more diverse during the first year of life.Preterm infants with lower gestational age harbor a higher relative abundance of potentially pathogenic genera in their early gut microbiota.However,the influence of gestational age on microbial composition diminishes over time.关键词
肠道菌群/胎龄/动态变化/16S rRNA测序/早产儿Key words
Gut microbiota/Gestational age/Dynamic change/16S rRNA sequencing/Preterm infant引用本文复制引用
宋绮莹,赵晓丽,丁碧蓝,吕倩,马丽亚..早产儿1～12月龄肠道菌群的动态变化[J].中国当代儿科杂志,2026,28(3):285-292,8.基金项目
国家自然科学基金青年基金项目(82204050) （82204050）
深圳市科技创新委员会基础研究项目(JCYJ201908809183601667、JCYJ20230807145901003) （JCYJ201908809183601667、JCYJ20230807145901003）
深圳市宝安区妇幼保健院科研基金(BAFY2021001). （BAFY2021001）
