中国肺癌杂志2026，Vol.29Issue(1)：47-58,12.DOI:10.3779/j.issn.1009-3419.2026.101.03
非小细胞肺癌淋巴结结外侵犯的临床意义:研究现状与展望
Clinical Significance of Extranodal Extension in Non-small Cell Lung Cancer:Current Status and Future Prospects
摘要
Abstract
Global cancer statistics in 2022 ranked lung cancer as the leading cause of cancer incidence and mortality worldwide,with lymph node metastasis serving as a pivotal determinant of prognosis and treatment strategy.Extranodal exten-sion(ENE)refers to the pathological phenomenon where tumor cells breach the lymph node capsule and invade surrounding tissues.In non-small cell lung cancer(NSCLC),although ENE has not yet been formally incorporated into the tumor-node-metastasis(TNM)staging system,its clinical value is gaining increasing attention.This review systematically summarizes the current research progress regarding the definition,diagnostic approaches,prognostic significance,and treatment implications of ENE in NSCLC,analyzes existing challenges,and proposes future directions.The goal of this paper is to provide insights for optimizing clinical practice and guiding subsequent research.关键词
肺肿瘤/结外侵犯/残留肿瘤/预后Key words
Lung neoplasms/Extranodal extension/Residual neoplasm/Prognosis引用本文复制引用
梁韩,孟娅洁,王琪,李才繁,杨昊,向旭东..非小细胞肺癌淋巴结结外侵犯的临床意义:研究现状与展望[J].中国肺癌杂志,2026,29(1):47-58,12.基金项目
This paper was supported by the grants from 2025 Degree and Graduate Education Innovation Fund Project of Kun-ming Medical University(No.2025S109,to Han LIANG （）
No.2025S271,to Yajie MENG). 本文受昆明医科大学2025年学位与研究生教育创新基金项目(No.2025S109,No.2025S271)资助 （No.2025S109,No.2025S271）
