中国肺癌杂志2026，Vol.29Issue(1)：59-67,9.DOI:10.3779/j.issn.1009-3419.2026.101.02
糖酵解重编程与乳酸化串扰在肿瘤中的研究进展
Research Progress on Glycolytic Reprogramming and Lactylation Crosstalk in Tumors
摘要
Abstract
Metabolic reprogramming is a hallmark of cancer,with the Warburg effect-driven aerobic glycolysis leading to a substantial accumulation of lactate in the tumor microenvironment.For a long time,lactate was considered a mere metabolic end product;however,recent studies have found that it acts as an important signaling molecule,profoundly influenc-ing tumor progression by inducing a novel post-translational modification-lactylation.Lactylation,driven by lactate,occurs on both histones and non-histone proteins and is finely regulated by the'writer''eraser'and'reader'mechanisms,thereby altering the function of target proteins and gene expression.This review systematically explores the bidirectional regulatory network between glycolytic reprogramming and lactylation:on one hand,key glycolytic regulators promote lactate production,thereby increasing lactylation levels;on the other hand,lactylation can feedback to regulate the activity and expression of key glycolytic enzymes,forming a pro-tumor positive feedback loop.This interaction plays a central role in tumor proliferation,metastasis,DNA damage repair,and immune evasion.Consequently,targeting lactate production,lactate transport,or the lactylation process itself has emerged as a highly promising anti-cancer strategy and shows potential synergy with existing therapies such as immune checkpoint inhibitors.In-depth analysis of the glycolysis-lactylation axis will provide a crucial theoretical basis for developing novel cancer treatment approaches.关键词
乳酸化修饰/糖酵解重编程/肿瘤微环境/免疫逃逸/靶向治疗Key words
Lactylation/Glycolytic reprogramming/Tumor microenvironment/Immune evasion/Targeted therapy引用本文复制引用
冯祎琳,赵西茹,孙颖,郝旭,杨慧彤,禄安琪,刘源,夏金婵,冯龙,蒋敏..糖酵解重编程与乳酸化串扰在肿瘤中的研究进展[J].中国肺癌杂志,2026,29(1):59-67,9.基金项目
This paper was supported by the grants from the National Natural Science Foundation of China(No.81803863,to Ying SUN),Henan Province Science and Technology R&D Joint Fund(Key Discipline Cultivation Category)Project(No.242301420105,to Ying SUN)and Henan Provincial Science and Technology Research Project(No.232102311111,to Ying SUN). 本文受国家自然科学基金项目(No.81803863)、河南省科技研发计划联合基金(优势学科培育类)项目(No.242301420105)和河南省科技攻关项目(No.232102311111)资助 （No.81803863,to Ying SUN）
