中国肺癌杂志2026，Vol.29Issue(1)：77-80,4.DOI:10.3779/j.issn.1009-3419.2026.102.01
成功使用白介素-6抗体托珠单抗控制肺腺癌顽固性肿瘤热1例病例报道
A Case Report of Successful Control of Refractory Tumor Fever in Lung Adenocarcinoma with Interleukin-6 Antibody Tocilizumab
摘要
Abstract
Fever is a common symptom of lung cancer,but most are induced by infection.This is the first report of a patient with lung adenocarcinoma who developed a fever of unknown origin for more than 1 month after repeat biopsy on the progression of first-line treatment in China.Comprehensive blood tests,the well-known pathogens were fully examined,and imaging studies failed to support infectious fever,connective tissue disease-related fever,drug fever,or other etiologies,lead-ing to the diagnosis of tumor fever.While the fever remained refractory to Ibuprofen,it was successfully controlled 12 h after a single intravenous administration of Tocilizumab,with the patient maintaining a normal body temperature for 45 days,from August 21 to October 4,2025.This case report primarily provides the practice for exploring the tumor fever.关键词
肺肿瘤/肿瘤热/白介素-6/托珠单抗Key words
Lung neoplasms/Paraneoplastic fever/Interleukin-6/Tocilizumab引用本文复制引用
李颖,李春辉,李斌..成功使用白介素-6抗体托珠单抗控制肺腺癌顽固性肿瘤热1例病例报道[J].中国肺癌杂志,2026,29(1):77-80,4.基金项目
This paper was supported by the grant from University-level Project of Central South University(No.2021JGB145,to Bin LI). 本文受中南大学校级项目(No.2021JGB145)资助 （No.2021JGB145,to Bin LI）
