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An innovative treatment for hypoxic-ischemic encephalopathy:Silk fibroin nanomaterials improve neural stem cell axon formation and facilitate cognitive improvement

Chao Han Shuna Chen Zihan Shi Xin Guan Wei Zou Jing Liu

中国神经再生研究（英文版）2026，Vol.21Issue(7)：3017-3025,9.

中国神经再生研究（英文版）2026，Vol.21Issue(7)：3017-3025,9.DOI:10.4103/NRR.NRR-D-24-01178

An innovative treatment for hypoxic-ischemic encephalopathy:Silk fibroin nanomaterials improve neural stem cell axon formation and facilitate cognitive improvement

Chao Han ¹Shuna Chen ²Zihan Shi ³Xin Guan ⁴Wei Zou ⁵Jing Liu⁴

作者信息

1. Stem Cell Clinical Research Center,National Joint Engineering Laboratory,Regenerative Medicine Center,The First Affiliated Hospital of Dalian Medical University,Dalian,Liaoning Province,China||Dalian Innovation Institute of Stem Cell and Precision Medicine,Dalian,Liaoning Province,China||College of Integrated Chinese and Western Medicine,Dalian Medical University,Dalian,Liaoning Province,China
2. Stem Cell Clinical Research Center,National Joint Engineering Laboratory,Regenerative Medicine Center,The First Affiliated Hospital of Dalian Medical University,Dalian,Liaoning Province,China||Dalian Innovation Institute of Stem Cell and Precision Medicine,Dalian,Liaoning Province,China||Department of Neurology,The First Affiliated Hospital of Dalian Medical University,Dalian,Liaoning Province,China
3. Dalian Innovation Institute of Stem Cell and Precision Medicine,Dalian,Liaoning Province,China||College of Integrated Chinese and Western Medicine,Dalian Medical University,Dalian,Liaoning Province,China
4. Stem Cell Clinical Research Center,National Joint Engineering Laboratory,Regenerative Medicine Center,The First Affiliated Hospital of Dalian Medical University,Dalian,Liaoning Province,China||Dalian Innovation Institute of Stem Cell and Precision Medicine,Dalian,Liaoning Province,China
5. Dalian Innovation Institute of Stem Cell and Precision Medicine,Dalian,Liaoning Province,China
折叠

摘要

关键词

astrocyte deactivation/axonal development/cognitive recovery/hypoxic-ischemic brain injury/motor function/nerve regeneration/neural stem cells/neurotrophic factor/silk fibroin hydrogel/synapse formation

Key words

引用本文复制引用

Chao Han,Shuna Chen,Zihan Shi,Xin Guan,Wei Zou,Jing Liu..An innovative treatment for hypoxic-ischemic encephalopathy:Silk fibroin nanomaterials improve neural stem cell axon formation and facilitate cognitive improvement[J].中国神经再生研究（英文版）,2026,21(7):3017-3025,9.

基金项目

This study was supported by the Dalian Science and Technology Talent Innovation Support Policy Implementation Plan High-Level Talent Team,No.2022RG18(to JL) （to JL）

the Science and Technology Plan Orientation of Liaoning Province,No.[2021]49(to JL) （to JL）

Dalian High-Level Talent Innovation Support Plan,No.2021RQ028(to CH) （to CH）

and the Natural Science Foundation of Liaoning Province,No.2022-BS-238(to CH). （to CH）

中国神经再生研究（英文版）

ISSN：1673-5374

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