张祯祯 1符州 1余勇夫 2张伶俐 3邵蓉 4金春林5
作者信息
- 1. 重庆医科大学附属儿童医院,重庆 400014
- 2. 复旦大学公共卫生学院,上海 200032
- 3. 中国药科大学国际医药商学院,江苏 南京 211198
- 4. 中国药科大学国家药物政策与医药产业经济研究中心,江苏 南京 211198
- 5. 上海市卫生和健康发展研究中心(上海市医学科学技术情报研究所),上海 200031
- 折叠
摘要
Abstract
Objective The study attempts to explore preferences and influencing factors among caregivers of children aged 1-4 years regarding antiviral treatment for influenza.It also seeks to quantify the relative importance of treatment attributes and provide evidence to optimize pediatric influenza treatment regimens and improve medication adherence.Methods From May to June 2025,a face-to-face survey was conducted among 108 caregivers of children aged 1-4 years with influenza in seven cities,including Beijing,Shanghai,and Chongqing,using stratified convenience sampling.The questionnaire collected data on caregiver demographics,pediatric influenza treatment information,and included discrete choice experiment(DCE)choice sets.A conditional logit model was used to analyze preference weights for different antiviral regimens.Relative importance and marginal rates of substitution(MRS)were calculated to quantify trade-offs among attributes.Results A total of 108 questionnaires were collected,of which 106 were valid.Caregivers placed the highest importance on the overall incidence of drug-related adverse events,followed by dosing frequency,time to fever resolution,taste,time to viral shedding cessation,and dosage form.The conditional logit model indicated significant preferences for an adverse event rate of 6%(β=1.49,P＜0.001),single-dose regimen(β=0.91,P＜0.001),2-day fever resolution(β=0.55,P＜0.001),and sweet taste(β=0.49,P＜0.001).Subgroup analysis showed that caregivers of children aged 1-2 years had stronger preferences for sweet taste,single-dose regimens,and lower adverse event rates than caregivers of children aged 3-4 years.Caregivers of children with a history of hospitalization favored regimens offering faster fever resolution and single-dose administration,but the difference is not statistically significant.Conclusions When selecting antiviral drugs for children aged 1-4 years with influenza,caregivers prioritize safety and convenience,particularly the incidence of adverse events and dosing frequency.These findings provide empirical evidence to inform the optimization of pediatric influenza treatment strategies,guide drug design,and support policy development.It is recommended that regulatory agencies incorporate patient preference evidence into pediatric drug evaluation and approval framework.Particular emphasis should be placed on convenience indicators,such as dosing frequency,to guide the R&D and approval of pediatric antiviral drugs that address clinical needs.关键词
离散选择实验/流感/儿童/照护者偏好/抗病毒药物Key words
discrete choice experiment/influenza/children/caregiver preference/antiviral drug分类
医药卫生
