中国现代医学杂志2026，Vol.36Issue(6)：7-12,6.DOI:10.3969/j.issn.1005-8982.2026.06.002
双歧杆菌联合维生素D对肥胖合并妊娠期糖尿病患者糖脂代谢水平及妊娠结局的影响
Effects of bifidobacteria combined with vitamin D on glucose and lipid metabolism and pregnancy outcomes in obese patients with gestational diabetes mellitus
摘要
Abstract
Objective To investigate the effects of bifidobacteria combined with vitamin D supplementation on glucose and lipid metabolism and pregnancy outcomes in obese patients with gestational diabetes mellitus(GDM).Methods One hundred and twenty obese women with GDM admitted to the 3201 Hospital between February 2023 and December 2024 were selected and randomly assigned by the envelope method to either a conventional group or a combined group,with 60 cases in each group.The conventional group received standard care,while the combined group received bifidobacteria plus vitamin D supplementation in addition to conventional treatment.The glucose and lipid metabolism,pancreatic β-cell function,body mass index(BMI),waist-to-hip ratio,and adverse pregnancy outcomes were compared between groups.Results The combined group exhibited greater differences in fasting blood glucose,2-hour postprandial glucose,and glycated hemoglobin levels before and after treatment compared to the conventional group(P＜0.05).The differences in triglycerides,total cholesterol,and low-density lipoprotein cholesterol levels before and after treatment in the combined group were greater than those in the conventional group(P＜0.05).The differences in the pancreatic β-cell function index,insulin resistance index,and fasting insulin levels before and after treatment in the combined group were greater than those in the conventional group(P＜0.05).The differences in BMI and the waist-to-hip ratio before and after treatment in the combined group were also greater than those in the conventional group(P＜0.05).The overall incidence of adverse pregnancy outcomes was lower in the combined group than in the conventional group(P＜0.05).Conclusion Bifidobacteria combined with vitamin D improves glucose and lipid metabolism,enhances pancreatic β-cell function,reduces insulin resistance,optimizes weight management,and lowers the incidence of adverse pregnancy outcomes in obese patients with GDM.关键词
肥胖合并妊娠期糖尿病/糖脂代谢/双歧杆菌/维生素D/妊娠结局Key words
obesity complicated by gestational diabetes mellitus/glucose and lipid metabolism/bifidobacteria/vitamin D/pregnancy outcomes分类
医药卫生引用本文复制引用
包春燕,徐郁,寇相欢..双歧杆菌联合维生素D对肥胖合并妊娠期糖尿病患者糖脂代谢水平及妊娠结局的影响[J].中国现代医学杂志,2026,36(6):7-12,6.基金项目
陕西省重点研发计划项目(No:2024SF-YBXM-240) （No:2024SF-YBXM-240）
