中国现代医学杂志2026，Vol.36Issue(6)：13-19,7.DOI:10.3969/j.issn.1005-8982.2026.06.003
血清Gal-1、VEGF预测重度子痫前期患者胎盘早剥的价值及危险因素分析
Predictive value of serum Gal-1 and VEGF for placental abruption in severe preeclampsia and identification of associated risk factors
摘要
Abstract
Objective To explore the clinical value of serum galectin-1(Gal-1)and vascular endothelial growth factor(VEGF)in assessing placental abruption(PA)in patients with severe preeclampsia(PE),and to analyze the associated risk factors.Methods A retrospective analysis was conducted on 231 patients with severe PE admitted to Northwest Women and Children's Hospital between January 2023 and January 2025.Based on the presence or absence of PA,patients were divided into the abruption group(n=46)and the non-abruption group(n=185).General clinical data and serum biomarker levels were collected and compared between the two groups.Multivariable logistic regression was used to identify risk factors for PA in severe PE patients.Receiver operating characteristic(ROC)curves were used to analyze the predictive value of each indicator for PA.Results The abruption group showed significantly higher levels of indirect bilirubin,creatinine,and blood urea nitrogen compared to the non-abruption group(P＜0.05),while the fibrinogen level was significantly lower in the abruption group(P＜0.05).Furthermore,the abruption group had significantly lower levels of Gal-1,IL-12,PLGF,Fibulin-5,and Ang-2(P＜0.05),but a significantly higher level of VEGF(P＜0.05).ROC curve analysis demonstrated that the combined biomarkers for predicting PA in severe PE patients yielded a sensitivity of 97.8％(95％CI:0.885,0.999),a specificity of 99.1％(95％CI:0.969,0.999),and an area under the curve of 0.977(95％CI:0.942,1.000).Multivariable logistic regression analysis revealed that a high VEGF level was an independent risk factor for PA in severe PE patients[(O^R)=3.025(95％CI:1.216,7.527),P＜0.05].Conversely,high levels of Gal-1[(O^R)=0.781(95％CI:0.679,0.899)],IL-12[(O^R)=0.824(95％CI:0.704,0.963)],PLGF[(O^R)=0.953(95％CI:0.912,0.996)],Fibulin-5[(O^R)=0.816(95％CI:0.742,0.897)],and Ang-2[(O^R)=0.570(95％CI:0.343,0.948)]were identified as independent protective factors(P＜0.05).Conclusion In patients with severe PE complicated by PA,serum levels of Gal-1,IL-12,PLGF,Fibulin-5,and Ang-2 are significantly decreased,while VEGF levels are elevated.The combined detection of Gal-1,VEGF,and other related biomarkers significantly enhances the predictive efficacy for PA.Elevated VEGF levels represent an independent risk factor,whereas higher levels of Gal-1,IL-12,and other related biomarkers act as protective factors.关键词
重度子痫前期/胎盘早剥/半乳糖凝集素-1/血管内皮生长因子/联合检测/危险因素Key words
severe preeclampsia/placental abruption/galectin-1/vascular endothelial growth factor/combined detection/risk factor分类
医药卫生引用本文复制引用
郭敏,秦莹..血清Gal-1、VEGF预测重度子痫前期患者胎盘早剥的价值及危险因素分析[J].中国现代医学杂志,2026,36(6):13-19,7.基金项目
陕西省重点研发计划一般项目(No:2022SF-055) （No:2022SF-055）
