中国现代医学杂志2026，Vol.36Issue(6)：34-40,7.DOI:10.3969/j.issn.1005-8982.2026.06.006
腭中缝成熟度评估体系与颅颌面骨缝发育关联性的研究进展
Advances in the association between the midpalatal suture maturation assessment system and craniofacial suture development
摘要
Abstract
This article systematically reviews recent advances in research on the association between the midpalatal suture maturation assessment system and craniofacial suture development.By analyzing the segmental anatomical characteristics of the midpalatal suture and its five-stage imaging-based classification(stages A-E),we elucidate the coordinated roles of the midpalatal suture and the craniofacial suture systems in developmental timing,biomechanical coupling,and molecular regulatory networks.Traditional histological classification methods(e.g.,the Melsen classification),limited by their invasiveness and subjectivity,are gradually being replaced by cone-beam computed tomography(CBCT)three-dimensional reconstruction and magnetic resonance T2 mapping techniques,while artificial intelligence-assisted image analysis has significantly improved assessment accuracy.The Wnt/BMP signaling pathways regulate suture development in a spatiotemporally specific manner;mesenchymal stem cells,such as mechanosensitive Piezo2+cells,mediate suture remodeling through mechanical responses;and mechanical stress generated by rapid maxillary expansion can activate adaptive growth of sutures.Together,these mechanisms constitute a key regulatory network governing suture development.In clinical practice,micro-implant-assisted rapid maxillary expansion optimizes stress distribution to achieve noninvasive skeletal effects,offering novel strategies for the treatment of craniofacial deformities.Future research should integrate imaging,biomechanical,and molecular detection techniques to elucidate the dynamic regulatory mechanisms of suture development and to develop novel therapeutic strategies based on targeted stem cell modulation,ultimately enabling precision diagnosis and treatment of craniofacial deformities.关键词
腭中缝成熟度/颅颌面骨缝发育/影像组学/生物力学耦合/分子调控网络Key words
midpalatal suture maturation/craniofacial suture development/radiomics/biomechanical coupling/molecular regulatory network分类
医药卫生引用本文复制引用
顾叶婷,刘曙,张军梅..腭中缝成熟度评估体系与颅颌面骨缝发育关联性的研究进展[J].中国现代医学杂志,2026,36(6):34-40,7.基金项目
贵州省卫生健康委科学技术基金项目(No:gzwkj2025-102,No:gzwkj2023-200) （No:gzwkj2025-102,No:gzwkj2023-200）
