中国药房2026，Vol.37Issue(6)：713-719,7.DOI:10.6039/j.issn.1001-0408.2026.06.04
芍药甘草汤自组装纳米粒的促吸收作用研究
Study on the absorption-enhancing effect of self-assembled nanoparticles from Shaoyao gancao decoction
摘要
Abstract
OBJECTIVE To investigate the effect and mechanism of self-assembled nanoparticles from Shaoyao gancao decoction(SGD-SAN)on the intestinal absorption behavior of its main active components.METHODS SGD-SAN was prepared and characterized.Using an in-situ single-pass intestinal perfusion model in rats,the absorption characteristics of five active components(albiflorin,paeoniflorin,liquiritin apioside,liquiritin,glycyrrhizic acid)from SGD-SAN in the jejunum and ileum were studied,with the absorption rate constant(Ka)and apparent permeability coefficient(Peff)as indicators,and compared with free drugs.In the intestinal segment with optimal absorption,the effects of drug concentration and efflux transporter inhibitors(P-glycoprotein inhibitor verapamil,multidrug resistance-associated protein 2 inhibitor indomethacin,breast cancer resistance protein inhibitor reserpine)on the intestinal absorption characteristics of these components were examined.RESULTS The obtained SGD-SAN exhibited a spherical shape with uniform sizes,an average particle diameter of(155.57±2.65)nm,a polydispersity index of 0.34±0.03,and a Zeta potential of(-9.30±1.12)mV.The average total content of five active components,including albiflorin,was 12.26%,and remained unaffected by enzymatic degradation and intestinal physical absorption.Compared with the free drug group,the five active components in the SGD-SAN group exhibited higher absorption rates in the ileal segment,with significantly elevated Ka and Peff values(except for the Peff value of glycyrrhizic acid in the ileal segment)(P＜0.05 or P＜0.01).Their absorption demonstrated a concentration-dependent trend.In the free drug groups,the absorption of each component was regulated by corresponding inhibitors(P＜0.05 or P＜0.01);whereas in the SGD-SAN groups,except for albiflorin and paeoniflorin,the absorption of the remaining components was not affected by the inhibitors(P＞0.05).CONCLUSIONS SGD-SAN significantly enhances the intestinal absorption efficiency of active components.The above absorption-enhancing effect may be related to the avoidance of efflux transporter influence and the presence of a mixed absorption mode.关键词
芍药甘草汤/自组装纳米粒/在体单向肠灌流/吸收速率常数/表观渗透系数/促吸收机制Key words
Shaoyao gancao decoction/self-assembled nanoparticles/in-situ single-pass intestinal perfusion/Ka/Peff/absorption-enhancing mechanism分类
医药卫生引用本文复制引用
魏欣玲,张双辰,张年战,何沂灿,杜超颖,申宝德,沈成英..芍药甘草汤自组装纳米粒的促吸收作用研究[J].中国药房,2026,37(6):713-719,7.基金项目
国家自然科学基金项目(No.82260848) （No.82260848）
江西省自然科学基金项目(No.20232BAB216139) （No.20232BAB216139）
江西中医药大学大学生创新创业训练计划项目(No.202510412257) （No.202510412257）
江西省赣鄱俊才支持计划·高层次高技能领军人才培养项目(No.赣人社字[2024]69号) （No.赣人社字[2024]69号）
