中国药房2026，Vol.37Issue(6)：823-828,6.DOI:10.6039/j.issn.1001-0408.2026.06.22
中药调控炎症微环境干预骨关节炎的机制研究进展
Research progress on the mechanism of traditional Chinese medicine intervening in osteoarthritis by modulating the inflammatory microenvironment
摘要
Abstract
The inflammatory microenvironment is closely associated with the initiation and progression of osteoarthritis(OA),specifically manifesting as macrophage activation,dysregulation of inflammatory cytokines,and redox imbalance.Following an overview of the pathological characteristics of the OA inflammatory microenvironment,this paper reviews the research progress on the mechanism of traditional Chinese medicine(TCM)intervening in OA by modulating the inflammatory microenvironment.It has been found that TCM monomers/active ingredients(such as total alkaloids from Strychnos nux-vomica,quercetin,triptolide,etc.),herb pairs(e.g.Angelica pubescens-Gentiana macrophylla,Carthami Flos-Lycopodii Herba),and TCM formulas(such as Zhuanggu jianxi formula,Duhuo jisheng decoction and Rongjin niantong formula,etc.)can inhibit macrophage activation,reduce the release of proinflammatory cytokines and the generation of reactive oxygen species by inhibiting multiple signaling pathways,including nuclear factor-κB,Wnt/β-catenin,and mitogen-activated protein kinase,thereby alleviating the articular inflammatory microenvironment,restoring local joint homeostasis,and slowing the progression of OA.关键词
骨关节炎/炎症微环境/中药单体/有效部位/药对/复方/作用机制Key words
osteoarthritis/inflammatory microenvironment/TCM monomer/active ingredients/herb pairs/TCM formulas/mechanism of action分类
医药卫生引用本文复制引用
王祚,刘禹欣,乔雨欣,杨政豫,王茹,廖文彬,高艳,冯佳怡,李国华..中药调控炎症微环境干预骨关节炎的机制研究进展[J].中国药房,2026,37(6):823-828,6.基金项目
内蒙古自治区自然科学基金面上项目(No.2025MS08153) （No.2025MS08153）
内蒙古自治区卫生健康中医药(蒙医药)科技计划项目(No.ZMY-2024103) （蒙医药）
内蒙古自治区医师协会临床医学研究和临床新技术推广项目(No.YSXH2024KYF020) （No.YSXH2024KYF020）
内蒙古自治区卫生健康委公立医院科研联合基金科技项目(No.2023GLLH0108) （No.2023GLLH0108）
鄂尔多斯市中医药(蒙医药)科技计划课题(No.ZMYY20250006) （蒙医药）
