中国药理学与毒理学杂志2025，Vol.39Issue(12)：933-946,14.DOI:10.3867/j.issn.1000-3002.2025.08627
基于纳米抗体的生物毒素检测与抗毒素治疗研究进展
Research progress in biotoxin detection and treatment based on nanobodies
陈雨婷 1李治 2马波 2谢剑炜 2安仁波 3徐华2
作者信息
- 1. 延边大学药学院,吉林 延吉 133002||军事医学研究院,北京 100850
- 2. 军事医学研究院,北京 100850
- 3. 延边大学药学院,吉林 延吉 133002
- 折叠
摘要
Abstract
Biotoxins are highly toxic substances derived from animals,plants and microorganisms.Due to their high toxicity,diversity,and ease of transmission,they are considered potential biological warfare agents and public health threats,and their detection and neutralization remain challenging.In recent years,nanobodies have emerged as a promising tool for both detection and treatment of toxins thanks to their small molecular weight,strong penetration,high stability,good binding affinity,and suit-ability for genetic engineering.This article reviews the structural characteristics,screening,and prepa-ration methods of nanobodies in general and the research progress in the detection and treatment of biotoxins(bacterial toxins,plant toxins,animal toxins,marine toxins and mycotoxins)in particular.Nano-body technology has shown great potential in biotoxin diagnosis and treatment,but its clinical transla-tion remains hindered by critical issues.Advancements depend on deep integration with cutting-edge technologies like artificial intelligence driven design.关键词
生物毒素/单克隆抗体/纳米抗体/检测/治疗/中和Key words
biotoxins/monoclonal antibody/nanobodies/detection/treatment/neutralization分类
医药卫生引用本文复制引用
陈雨婷,李治,马波,谢剑炜,安仁波,徐华..基于纳米抗体的生物毒素检测与抗毒素治疗研究进展[J].中国药理学与毒理学杂志,2025,39(12):933-946,14.
