中国药物评价2026，Vol.43Issue(1)：9-13,5.
医用镁基材料表面改性技术的研究进展与应用展望
Surface Modification of Medical Magnesium-Based Materials:Advances and Perspectives
摘要
Abstract
Magnesium-based materials demonstrate significant potential for applications in orthopedic,cardiovascular,and other medi-cal device fields due to their excellent biodegradability,favorable mechanical compatibility,and bioactivity.However,challenges such as excessively rapid degradation rates,localized gas formation,and elevated pH in physiological environments have hindered their clinical translation.This review systematically examines the corrosion mechanisms of magnesium-based materials and the specific challenges it faces in various physiological milieus(e.g.,bone tissue,blood vessels,and the digestive system).It highlights recent advances in sur-face modification technologies,including chemical conversion,micro-arc oxidation,polymer coatings,and composite coatings,to enhance the corrosion resistance,biocompatibility,and functional properties(e.g.,osteogenic promotion,antibacterial effects,and endothelial-ization capability)of these materials.Studies indicate that surface modifications can effectively regulate the degradation behavior of mag-nesium-based materials,achieving synchronized degradation and tissue regeneration.These findings provide both theoretical support and technical strategies for the further development of degradable magnesium-based implantable medical devices.关键词
镁/生物可降解/耐腐蚀/医疗器械/体内外研究Key words
Magnesium/Biodegradable/Corrosion resistance/Medical devices/In vitro and in vivo study分类
医药卫生引用本文复制引用
曲春鸽,江珊,尤茗语,田甜..医用镁基材料表面改性技术的研究进展与应用展望[J].中国药物评价,2026,43(1):9-13,5.基金项目
上海市科学技术委员会项目(24692122800) （24692122800）
