中国药物评价2026，Vol.43Issue(1)：24-31,8.
基于知识图谱的大理民族民间痹证单验方用药规律研究
A Knowledge Graph-Based Study on the Medication Rules of Dali Ethnic Folk Empirical Prescriptions for Bi Syndrome
摘要
Abstract
Objective:To construct a knowledge graph of Dali ethnic folk empirical prescriptions for Bi syndrome using knowledge graph techniques,to identify formula-herb compatibility patterns,and to explore the application value of knowledge graphs in ethnic folk medicine research.Methods:Medical literature from the Dali region was systematically collected through sources such as Chinese Medi-cal Works in Different Provinces,local gazetteers,and folk empirical prescriptions for Bi syndrome were collected.Ontology-based knowl-edge modeling was employed,followed by knowledge extraction,representation,storage,and visualization to construct the knowledge graph,which was implemented in the Neo4j graph database.On this basis,graph algorithms and community detection methods were applied to analyze the multi-relational knowledge network centered on the"formula-herb"relationship.Results:A knowledge graph com-prising 773 entities and 1172 relationships was constructed,forming a multi-relational knowledge network centered on the"formula-herb"structure.Three core formulas were identified,and their shared herbs(Duzhong,Duhuo,Qinjiao and Qianghuo)constituted the core herbal combination.Among them,Xuduan was identified as the most central herb,followed by Danggui.In addition,key characteristic ethnic medicinal herbs represented by Qingyangshen,Qiannianjian,and Shijiaocao were identified,revealing their potential clinical appli-cation value.Conclusion:This study systematically presents the"formula-herb"knowledge network of Dali ethnic folk empirical pre-scriptions for Bi syndrome,revealing therapeutic principles characterized by dispelling pathogenic factors while supporting healthy qi and tonifying the liver and kidney,and highlighting distinct regional medicinal characteristics.By applying knowledge graph techniques and graph-theoretical algorithms to small-sample and highly sparse folk prescription data,this study provides a reusable methodological frame-work for the scientific and standardized research on ethnic folk empirical prescriptions.关键词
民族民间单验方/痹证/知识图谱/数据挖掘Key words
Ethnic folk empirical prescriptions/Bi syndrome/Knowledge graph/Data mining分类
医药卫生引用本文复制引用
马铮然,黄子易,王肖盈,杨文龙,朱志伟..基于知识图谱的大理民族民间痹证单验方用药规律研究[J].中国药物评价,2026,43(1):24-31,8.基金项目
云南省科技厅中医联合专项-面上项目(20202301AZ070001-115) （20202301AZ070001-115）
云南省科技厅中医联合专项-青年项目(202301AZ070001-178) （202301AZ070001-178）
云南省科技厅中医联合专项-青年项目(202401AZ070001-141) （202401AZ070001-141）
云南中医药大学校院联合基金项目-重点项目(XYLH2024023) （XYLH2024023）
