中国药物评价2026，Vol.43Issue(1)：39-45,7.
山楂中有效成分及其治疗非酒精性脂肪肝的作用机制研究进展
Research Progress on the Active Constituents of Cratargi Fructus and Their Mechanism of Action in Treating Nonalcoholic Fatty Liver Disease
摘要
Abstract
Objective:To systematically summarizes the primary active constituents in Cratargi Fructus and their mechanism of action in the treatment of non-alcoholic fatty liver disease(NAFLD),aiming to provide a reference for the clinical application,in-depth research,and development and utilization of Cratargi Fructus for the treatment of NAFLD.Methods:This study employed a systematic literature review method,utilizing keywords such as"Cratargi Fructus"and"nonalcoholic fatty liver disease",to conduct searches in domestic and international databases including CNKI,Web of Science,and PubMed.It comprehensively reviews the research progress on the active constituents of Cratargi Fructus and their mechanisms of action in treating NAFLD in recent years.Results and Conclusion:Cratargi Fructus is rich in active constituents such as flavonoids,organic acids,triterpenes,and polysaccharides.It can reduce hepatic fat deposi-tion,inhibit lipid peroxidation,alleviate hepatic inflammation injury,and prevent liver fibrosis through multiple pathways.These include regulating lipid metabolism,exerting antioxidant and anti-inflammatory effects,modulating the gut microbiota,and providing anti-fibrotic effects.The characteristic multi-component,multi-target,and multi-pathway regulatory profile of Cratargi Fructus demonstrates unique potential in the and treatment of NAFLD.关键词
山楂/有效成分/非酒精性脂肪肝/作用机制Key words
Cratargi Fructus/Active constituents/Nonalcoholic fatty liver disease(NAFLD)/Mechanism of action分类
医药卫生引用本文复制引用
代琪,桂子雅,董兆威,叶俏波,罗霄,张良..山楂中有效成分及其治疗非酒精性脂肪肝的作用机制研究进展[J].中国药物评价,2026,43(1):39-45,7.基金项目
国家重点研发计划项目(2023YFC3504100) （2023YFC3504100）
四川省药品监督管理局科技计划项目(2025005) （2025005）
成都市药品化妆品安全风险研究项目(2025FX04) （2025FX04）
