中国癌症防治杂志2026，Vol.18Issue(1)：36-42,7.DOI:10.3969/j.issn.1674-5671.2026.01.05
术后辅助性经导管动脉化疗栓塞术对细胞角蛋白19阳性肝细胞癌患者预后的影响:一项倾向性评分匹配队列研究
Impact of postoperative adjuvant-transcatheter arterial chemoembolization on postoperative prognosis in cytokeratin 19-positive hepatocellular carcinoma patients:a propensity score matching cohort study
摘要
Abstract
Objective To investigate the prognostic value of postoperative adjuvant-transcatheter arterial chemoembolization(PA-TACE)in patients with cytokeratin 19(CK19)-positive hepatocellular carcinoma(HCC).Methods This single-center retrospective cohort analysis enrolled patients with pathologically confirmed CK19-positive HCC who underwent radical hepatectomy at Guangxi Medical University Cancer Hospital from January 2013 to December 2018.Participants were stratified into the PA-TACE group(n=125)and Non-TACE group(n=255)based on postoperative receipt of PA-TACE.A 1∶1 propensity score matching(PSM)procedure was performed between the two groups,and differences in relapse-free survival(RFS)and overall survival(OS)were compared between the two groups pre-and post-PSM.Results In a cohort of 380 patients,pre-PSM analysis showed that the PA-TACE group was younger,exhibited a higher rate of hepatitis B virus infection,and a higher proportion of multiple tumors compared with the Non-TACE group(all P<0.05).Across entire cohort,the median RFS in the PA-TACE group was significantly longer than that in the Non-TACE group(18.0 months vs 8.0 months;HR=0.69,95%CI:0.52-0.91,P<0.001),and the median OS was also significantly improved(not reached vs 39.0 months;HR=0.67,95%CI:0.49-0.92,P=0.013).Following PSM,124 matched patient pairs were obtained,and the PA-TACE group still had superior median RFS(17.0 months vs 7.0 months;HR=0.69,95%CI:0.50-0.95,P<0.001)and median OS(not reached vs 41.0 months;HR=0.69,95%CI:0.48-0.99,P=0.044)compared with the Non-TACE group.Conclusions In this retrospective cohort study of patients CK19-positive HCC,postoperative PA-TACE was associated with prolonged RFS and OS.These findings suggest that PA-TACE may serve as a beneficial adjuvant therapeutic strategy for this population.关键词
肝细胞癌/细胞角蛋白19/肝切除术/术后辅助性经导管动脉化疗栓塞术Key words
Hepatocellular carcinoma/Cytokeratin 19/Hepatectomy/Postoperative adjuvant-transcatheter arterial chemoembolization分类
医药卫生引用本文复制引用
黄宏阳,林燕,梁嵘,邬国斌,叶甲舟,麦荣云,陶政,曾璨,莫凯翔,岑伟杰,曾丹丹,罗文凤,苏靖婷,苏月娇..术后辅助性经导管动脉化疗栓塞术对细胞角蛋白19阳性肝细胞癌患者预后的影响:一项倾向性评分匹配队列研究[J].中国癌症防治杂志,2026,18(1):36-42,7.基金项目
广西自然科学基金项目(2025GXNSFBA069552) （2025GXNSFBA069552）
国家自然科学基金项目(82560610 （）
82460611) （）
广西医科大学附属肿瘤医院青年科学基金资助项目(院青基2023-7号) （院青基2023-7号）
2024年度广西高校中青年教师科研基础能力提升项目(2024KY0133) （2024KY0133）
