中国癌症防治杂志2026，Vol.18Issue(1)：43-50,8.DOI:10.3969/j.issn.1674-5671.2026.01.06
BMI水平对肝脏病变患者动脉期呼吸运动伪影的影响:基于钆塞酸二钠增强MRI
Effect of BMI levels on arterial phase respiratory motion artifacts in patients with liver dis-ease:based on gadoxetic acid disodium enhanced MRI
摘要
Abstract
Objective Gadoxetic acid disodium(Gd-EOB-DTPA)enhanced magnetic resonance imaging(MRI)plays a crucial role in the detection and characterization of hepatic lesions,However,arterial phase images are frequently degraded by transient severe motion(TSM)artifacts,which may be associated with body mass index(BMI).This study aims to investigate the relationship and dose-response association between BMI and TSM in Gd-EOB-DTPA enhanced MRI,and to provide the evidence for the accurate identification and prevention of arterial-phase TSM.Methods This prospective study enrolled patients with liver lesions who underwent Gd-EOB-DTPA enhanced MRI at Guangxi Medical University Cancer Hospital from March 2024 to November 2025.Multivariable Logistic regression was used to evaluate the association between BMI and arterial-phase TSM.Four stepwise adjusted models were established.Model 1 was unadjusted,Model 2 adjusted for demographic factors,Model 3 additionally included lifestyle factors,and Model 4 was comprehensively adjusted for clinical covariates.Subgroup analysis was performed to observe the correlation between BMI and arterial TSM across different populations.Restricted cubic splines(RCS)were applied to explore potential non-linear relationships.Results A total of 792 patients were included in the study and categorized into three groups:the underweight/normal-weight group(n=484),the overweight group(n=158),and the obese group(n=150).Arterial-phase TSM occurred in 270 patients(34.1%).After adjustment for relevant confounders,compared with the underweight/normal-weight group,the obese group had a significantly higher risk of arterial-phase TSM(OR=2.88,95%CI:1.82-4.55;P<0.001).A 1-standard-deviation increase in BMI(4.51 kg/m²)was associated with a 49%higher risk of arterial-phase TSM(OR=1.49,95%CI:1.26-1.77;P<0.001).RCS analysis showed a linear positive association between BMI and arterial-phase TSM within a BMI range of 15-40 kg/m²(P for overall association<0.001;P for nonlinearity=0.927).Subgroup analyses indicated a significant interaction between prior Gd-EOB-DTPA enhanced MRI history and the BMI-TSM association(P for interaction=0.016).Conclusions Obesity is an independent risk factor for arterial-phase TSM on Gd-EOB-DTPA enhanced MRI,and the risk of arterial-phase TSM increasing with BMI.Clinical practice should pay particular attention to patients with elevated BMI,especially those undergoing first-time examinations,by implementing implement targeted preparation and acquisition strategies to improve arterial-phase image quality.关键词
肝脏肿瘤/钆塞酸二钠/增强MRI/呼吸运动伪影/身体质量指数/肥胖Key words
Liver cancer/Gadoxetic acid disodium/Enhanced MRI/Respiratory motion artifact/Body mass index/Obesity分类
医药卫生引用本文复制引用
黄富玲,卢飞臣,邱富河,潘海辉,杨郑楠,朱旭娜,李强,罗宁斌..BMI水平对肝脏病变患者动脉期呼吸运动伪影的影响:基于钆塞酸二钠增强MRI[J].中国癌症防治杂志,2026,18(1):43-50,8.基金项目
国家自然科学基金项目(82560356) （82560356）
广西重点研发计划项目(桂科AB24010038) （桂科AB24010038）
北京医学奖励基金会项目(睿影科研基金第六期项目)(YXJL-2024-0350-0314) （睿影科研基金第六期项目）
