中国中药杂志2026，Vol.51Issue(5)：1217-1228,12.DOI:10.19540/j.cnki.cjcmm.20251028.302
中药纳米科学:方剂纳米体原理与中药先进治疗制剂
Traditional Chinese medicine nanoscience:principles of formula-derived nanoparticles and advanced TCM therapeutic preparations
摘要
Abstract
As a frontier field integrating traditional Chinese medicine(TCM)theory with modern nanotechnology,traditional Chinese medicine nanoscience(TCMN)is spearheading revolutionary breakthroughs in the modernization of TCM.Innovative breakthroughs in TCM nanoscience are mainly reflected in the formula-derived nanoparticles of TCM(FDN)and the formula-derived nanoparticles drug discovery(FDD),intelligent delivery of multi-active components in TCM,precision design of nanocarrier systems,and technological innovations through multidisciplinary integration.TCMN transforms the"dark knowledge"of formula combinations into quantifiable and controllable"explicit knowledge",enabling scientific interpretation of the complex systems within TCM at the nanoscale.The formation and development of the TCMN and the principles of formula-derived nanoparticles will greatly advance the interpretation of TCM principles and their therapeutic advantages:clarifying clearly material basis(discovery of novel micro-and nano-scale active substances),elucidating the mechanism of action(multi-level dynamic network regulatory mechanism),developing innovative drugs(multi-target advanced therapy medicinal products based on TCM),and inheriting the essence(enhancing its therapeutic advantages of TCM).The future development of TCMN will exhibit distinct characteristics of in-depth multidisciplinary integration,technological paradigm innovation,and industrial ecosystem reconstruction.It is not only expected to break through the technical bottlenecks and regulatory issues currently faced by advanced therapy medicinal products of TCM,but also create a brand-new model for TCM in treating complex diseases.Furthermore,it will play an increasingly important role in treating major diseases and safeguarding human health,opening up unprecedented broad prospects for the inheritance,innovation,and international development of TCM.关键词
纳米技术/纳米中药/中药纳米科学/方剂纳米体/方剂纳米体药物发现/中药先进治疗制剂/新药发现/监管科学Key words
nanotechnology/nano-traditional Chinese medicine/TCM nanoscience/formula-derived nanoparticles of TCM/formu-la-derived nanoparticles drug discovery/advanced TCM therapeutic preparations/new drug discovery/regulatory science引用本文复制引用
华桦,陈春英,赵军宁,蔡双飞,孙全梅,曹明晶,刘晶,李东影,艾彦伶,谢小雪,纪艳玲..中药纳米科学:方剂纳米体原理与中药先进治疗制剂[J].中国中药杂志,2026,51(5):1217-1228,12.基金项目
国家自然基金委基础科学中心项目(22388101) （22388101）
新基石项目(NCI202318) （NCI202318）
国家纳米科学中心研究所自主部署科研类项目(E59651R1) （E59651R1）
四川省中医药管理局科学技术研究专项重大项目(25ZDAZX007) （25ZDAZX007）
