中国中药杂志2026，Vol.51Issue(5)：1250-1258,9.DOI:10.19540/j.cnki.cjcmm.20251219.501
中药在免疫检查点抑制剂抗肿瘤治疗中的增效减毒作用与研究进展
Efficacy-enhancing and toxicity-reducing effects of TCM in immune checkpoint inhibitor-based anti-tumor therapy:a review of mechanisms and advances
摘要
Abstract
Immune checkpoint inhibitors(ICIs)have become a significant breakthrough in cancer therapy by activating anti-tumor immune responses through the blockade of immune checkpoint molecules.However,acquired resistance to ICIs and immune-related adverse events(irAEs)severely limit their clinical application.TCM,based on the principles of holistic view and syndrome differentiation-based treatment,demonstrates distinct advantages in enhancing ICIs efficacy due to its unique immunomodulatory effects and multi-target,multi-pathway mechanisms.Studies suggest that TCM may effectively enhance T cell-mediated anti-tumor activity and improve ICIs resistance through various mechanisms,including modulating the tumor microenvironment,intervening in key immune signaling pathways,and restoring gut microbiota homeostasis.Additionally,TCM shows promising potential in alleviating ICIs-induced irAEs,such as colitis,pneumonitis,and cardiotoxicity,thereby improving patient tolerance to treatment.This review systematically summarizes the synergistic mechanisms and recent research progress in the combined use of TCM and ICIs,aiming to provide novel insights for optimizing cancer immunotherapy strategies.In the future,a precision medicine model integrating TCM and western medicine may offer safer and more effective therapeutic options for cancer patients,further advancing the development of tumor immunotherapy.关键词
癌症/中药/免疫检查点抑制剂/免疫相关不良事件/肿瘤微环境Key words
cancer/TCM/immune checkpoint inhibitor/immune-related adverse event/tumor microenvironment引用本文复制引用
王渲强,陈炜聪,赵璐..中药在免疫检查点抑制剂抗肿瘤治疗中的增效减毒作用与研究进展[J].中国中药杂志,2026,51(5):1250-1258,9.基金项目
国家重点研发计划项目(2024YFC3506601) （2024YFC3506601）
