中国中药杂志2026，Vol.51Issue(5)：1367-1372,6.DOI:10.19540/j.cnki.cjcmm.20251203.201
青钱柳果实中2个新化合物及α-葡萄糖苷酶抑制活性研究
Two new compounds from Cyclocarya paliurus fruits and their α-glucosidase inhibitory activity
摘要
Abstract
This study aims to isolate and identify the chemical constituents of Cyclocarya paliurus fruits.The constituents were isolated and purified by silica gel,Sephadex LH-20,and semi-preparative high performance liquid chromatography.Their structures were elucidated by a combination of IR,UV,HR-ESI-MS,NMR,and CD spectra.Four compounds(1-4)were successfully isolated from the 80%ethanol extract of the dried fruits,and they were identified as qingqianliulignanoside A(1),cyclopaloside E(2),emodin-8-O-β-D-glucoside(3),and daucosterol(4).Compounds 1 and 2 were new compounds,and compounds 3 was isolated from C.paliurus for the first time.The inhibitory activities of compounds 1-3 against α-glucosidase were assessed via the PNPG method.Compounds 2 exhibited certain α-glucosidase inhibitory activity,with the IC50 value of(148.3±11.4)μg·mL-1.关键词
青钱柳果实/α-葡萄糖苷酶/新木脂素苷/四氢萘酮苷Key words
Cyclocarya paliurus fruits/α-glucosidase/neolignan glycoside/tetralone glycoside引用本文复制引用
胡琪琪,戴灵彦,黄沁,朱悦晴,肖金泊,谭李宏,袁汉文,王炜,翦雨青..青钱柳果实中2个新化合物及α-葡萄糖苷酶抑制活性研究[J].中国中药杂志,2026,51(5):1367-1372,6.基金项目
国家自然科学基金项目(81803708) （81803708）
湖南省教育厅优秀青年项目(22B0388) （22B0388）
湖南中医药大学2025年大学生创新训练计划项目(X202510541043) （X202510541043）
